Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
| العنوان: | Allogeneic Stem Cell Transplantation with CD34+ Cell Selection |
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| المؤلفون: | Pere Barba, Miguel-Angel Perales, Elisa Roldán |
| المصدر: | Clinical Hematology International Clinical Hematology International, Vol 1, Iss 3 (2019) |
| بيانات النشر: | Atlantis Press, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, business.industry, lcsh:R, CD34, lcsh:Medicine, Graft-versus-host disease-free and relapse-free survival (GRFS), T-cell depletion, Disease, Review, Review Article, medicine.disease, CD34+ cell selection, Graft-versus-host disease, Allogeneic transplant, Transplantation, surgical procedures, operative, Internal medicine, Toxicity, Medicine, Stem cell, business, T cell depletion, Selection (genetic algorithm) |
| الوصف: | The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft-versus-host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients. In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice. |
| اللغة: | English |
| تدمد: | 2590-0048 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e67bbe5f4eabd7e0fa6575e27b475fTest http://europepmc.org/articles/PMC8432362Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....36e67bbe5f4eabd7e0fa6575e27b475f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25900048 |
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