التفاصيل البيبلوغرافية
| العنوان: |
Stage IV Epstein-Barr Virus-Associated Early Gastric Cancer and Comparative Analysis of Genetic Alterations in Primary and Metastatic Tumors. |
| المؤلفون: |
Hong Jun Kim1, Chi Hoon Maeng1, Ji-Youn Sung2, Kiyong Na2 raripapa@gmail.com |
| المصدر: |
Journal of Nippon Medical School. 2020, Vol. 87 Issue 6, p350-354. 5p. |
| مصطلحات موضوعية: |
*STOMACH cancer, *CELL nuclei, *METASTASIS, *TUMORS, *NUCLEOTIDE sequencing |
| مستخلص: |
Early gastric cancer (EGC) with synchronous distant metastasis is extremely rare. Here, we report a case of stage IV Epstein-Barr virus (EBV)-associated EGC. A 51-year-old man presented with vague abdominal pain of 3 weeks' duration. Imaging studies revealed enlargement of the left supraclavicular, perigastric, and para-aortic lymph nodes, a huge gastric polypoid mass, and multiple liver masses. Histopathological examination of a biopsy specimen of the supraclavicular lymph node showed poorly differentiated carcinoma expressing EBV in tumor cell nuclei. The gastric mass exhibited tubular adenocarcinoma, which also expressed EBV in tumor cell nuclei. After 3 weeks of palliative chemotherapy with fluoropyrimidine and platinum, the patient died of liver failure. Next-generation sequencing analysis revealed mutation of the CDKN1B gene in the metastatic carcinoma and mutations of the CTNNB1 and PIK3R1 genes in the gastric carcinoma. In addition to the rare presentation of EBV-associated EGC, this case showed marked morphological and molecular differences between primary and metastatic tumors, which suggests clonal evolution of EBV-associated GC. [ABSTRACT FROM AUTHOR] |
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