Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion
| العنوان: | Evaluation of adenosine deaminase activity for diagnosis of tuberculous pleural effusion |
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| المؤلفون: | M Ibrahim, M Ahamad, SK Bhoumik, MM Hiron, MM Rahman |
| المصدر: | Journal of Pathology of Nepal, Vol 3, Iss 5, Pp 367-373 (2013) |
| بيانات النشر: | Association of Clinical Pathologists of Nepal, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Tuberculosis, biology, business.industry, Pleural effusion, Diagnostic tools, medicine.disease, Gastroenterology, Surgery, Pleural Effusion, Tuberculous pleural effusion, Adenosine deaminase, Internal medicine, biology.protein, lcsh:Pathology, Medicine, In patient, business, Diffi cult, Infectious agent, lcsh:RB1-214 |
| الوصف: | Background: Tuberculosis is a leading cause of worldwide preventable morbidity and mortality from an infectious agent. A defi nite diagnosis of tubercular pleural effusion can be diffi cult to make because of low sensitivity and/or specifi city of noninvasive traditional diagnostic tools. This study is done to fi nd out a sensitive and specifi c marker for early diagnosis of tuberculous pleural effusion. Materials and Methods: One hundred and three pleural effusion cases were enrolled in the study, out of which 62 were tuberculous pleural effusion cases and 49 were non-tuberculous cases. Results: Considering 40 U/L as a cut off value for Adenosine deaminase assay level, the test result was positive in 58 out of 62 patients of tuberculosis indicating sensitivity of the test as 94%; however, among 41 non-tuberculous patients, 5 presented ADA activity level more than 40U/L, which lowers the specifi city of the test to 88%. ADA levels were signifi cantly higher in tuberculous than in non tuberculous cases (P value Conclusion: It may be concluded that ADA levels are signifi cantly high in patients with tuberculous pleural effusion compared to that in non tuberculous group. Sensitivity (94%) and specifi city (88%) of the test in tuberculous pleural effusions are very high, when cut off value set at 40U/L. The result indicated that the analysis of ADA levels in pleural effusion constitute a very useful marker for the diagnosis of TPE which, in addition, can be made quickly in a non- invasive way. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 367-373 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7860Test |
| اللغة: | English |
| تدمد: | 2091-0908 2091-0797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d907daf705bf1b706f3148067ae120dTest http://www.nepjol.info/index.php/JPN/article/view/7860Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d907daf705bf1b706f3148067ae120d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20910908 20910797 |
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