دورية أكاديمية
Process Evaluation of Sugar-Based Polymeric Colloidal Nanocarrier Formation
| العنوان: | Process Evaluation of Sugar-Based Polymeric Colloidal Nanocarrier Formation |
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| المؤلفون: | Thais Aragão Horoiwa, Adriano Marim de Oliveira, Amanda Migotto, Natalia Neto Pereira Cerize |
| المصدر: | Materials Research, Vol 22, Iss 2 (2019) |
| بيانات النشر: | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol), 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials |
| مصطلحات موضوعية: | polymeric colloidal nanocarrier, block copolymer, silicone surfactants, maltodextrin, Materials of engineering and construction. Mechanics of materials, TA401-492 |
| الوصف: | Abstract Several studies have demonstrated that sugar-based nanocarriers are recommended to develop drug delivery systems since they are biocompatible and biodegradable and might improve the therapeutic index of currently used drugs by reducing their toxicity and enhancing their bioavailability. Therewith, this work studied the processing conditions to formation of a sugar-based nanocarrier denominated polymeric colloidal nanocarriers (PCN). It reports the impact of emulsifiers types and concentration, salt concentration and copolymers addition on physical stability and particle size distribution of a maltodextin-based PCN. In order to define the most stable formulation to produce the maltodextrin nanocarriers, 13 PCN formulations were evaluated in respect to kinetic stability, particle size distribution and morphology. The results demonstrated that to have a stable sugar-based PCN in silicone for at least 3 days, it is necessary to work with Poloxamer 188 as a copolymer, SF 1540 surfactant in a concentration proportional to the solid content and a salt concentration of 0.4 %. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1516-1439 1980-5373 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392019000200219&tlng=enTest; http://www.scielo.br/pdf/mr/v22n2/1516-1439-mr-22-02-e20180074.pdfTest; https://doaj.org/toc/1516-1439Test |
| DOI: | 10.1590/1980-5373-mr-2018-0074 |
| الوصول الحر: | https://doaj.org/article/088c86e7db014a96884b70435bbd14afTest |
| رقم الانضمام: | edsdoj.088c86e7db014a96884b70435bbd14af |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15161439 19805373 |
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| DOI: | 10.1590/1980-5373-mr-2018-0074 |