Glucocorticoids, master modulators of the thymic catecholaminergic system?
| العنوان: | Glucocorticoids, master modulators of the thymic catecholaminergic system? |
|---|---|
| المؤلفون: | G Leposavi, Zorica Stojić-Vukanić, D Kosec, K. Radojević, Milica Perišić, Vesna Pešić, Ivan Pilipović |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 43, Iss 3, Pp 279-284 (2010) Brazilian Journal of Medical and Biological Research, Volume: 43, Issue: 3, Pages: 279-284, Published: MAR 2010 Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research, Vol 43, Iss 3, Pp 279-284 |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, Physiology, medicine.medical_treatment, beta-adrenoceptors, Apoptosis, CD8-Positive T-Lymphocytes, Biochemistry, 0302 clinical medicine, Catecholamines, General Pharmacology, Toxicology and Pharmaceutics, Thymocyte differentiation, lcsh:QH301-705.5, Catecholaminergic, 0303 health sciences, lcsh:R5-920, Thymocyte proliferation, General Neuroscience, Adrenalectomy, Cell Differentiation, General Medicine, Organ Size, Flow Cytometry, Propranolol, Thymocyte, Phenotype, lcsh:Medicine (General), medicine.drug, medicine.medical_specialty, Adrenergic receptor, Immunology, Adrenergic beta-Antagonists, Biophysics, β-adrenoceptors, Thymus Gland, Biology, 03 medical and health sciences, Immune system, Internal medicine, medicine, Animals, Glucocorticoids, 030304 developmental biology, Cell Proliferation, Cell Biology, Rats, Endocrinology, lcsh:Biology (General), Catecholamine, 030217 neurology & neurosurgery, CD8, Thymocyte apoptosis |
| الوصف: | There is evidence that the major mediators of stress, i.e., catecholamines and glucocorticoids, play an important role in modulating thymopoiesis and consequently immune responses. Furthermore, there are data suggesting that glucocorticoids influence catecholamine action. Therefore, to assess the putative relevance of glucocorticoid-catecholamine interplay in the modulation of thymopoiesis we analyzed thymocyte differentiation/maturation in non-adrenalectomized and andrenalectomized rats subjected to treatment with propranolol (0.4 mg.100 g body weight(-1).day(-1)) for 4 days. The effects of beta-adrenoceptor blockade on thymopoiesis in non-adrenalectomized rats differed not only quantitatively but also qualitatively from those in adrenalectomized rats. In adrenalectomized rats, besides a more efficient thymopoiesis [judged by a more pronounced increase in the relative proportion of the most mature single-positive TCR alpha beta(high) thymocytes as revealed by two-way ANOVA; for CD4(+)CD8(-)F (1,20) = 10.92, P lt 0.01; for CD4(-)CD8(+)F (1,20) = 7.47, P lt 0.05], a skewed thymocyte maturation towards the CD4(-)CD8(+) phenotype, and consequently a diminished CD4(+)CD8(-)/CD4(-)CD8(+) mature TCR alpha beta(high) thymocyte ratio (3.41 +/- 0.21 in non-adrenalectomized rats vs 2.90 +/- 0.31 in adrenalectomized rats, P lt 0.05) were found. Therefore, we assumed that catecholaminergic modulation of thymopoiesis exhibits a substantial degree of glucocorticoid-dependent plasticity. Given that glucocorticoids, apart from catecholamine synthesis, influence adrenoceptor expression, we also hypothesized that the lack of adrenal glucocorticoids affected not only beta-adrenoceptor- but also alpha-adrenoceptor-mediated modulation of thymopoiesis. |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2583161f23b72787479f7a2f9a7c68deTest http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300009Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2583161f23b72787479f7a2f9a7c68de |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |