Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population
| العنوان: | Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population |
|---|---|
| المؤلفون: | X.-X. Zhao, Y.-L. Wei, G.-Z. Qiu, Q. Tian, Ying Xu |
| المصدر: | Brazilian Journal of Medical and Biological Research, Volume: 50, Issue: 6, Article number: e5758, Published: 15 MAY 2017 Brazilian Journal of Medical and Biological Research, Vol 50, Iss 6 Brazilian Journal of Medical and Biological Research v.50 n.6 2017 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Physiology, Kaplan-Meier Estimate, Biochemistry, Gastroenterology, GTP Phosphohydrolases, 0302 clinical medicine, Gene Frequency, Risk Factors, Genotype, Medicine, General Pharmacology, Toxicology and Pharmaceutics, lcsh:QH301-705.5, lcsh:R5-920, General Neuroscience, digestive, oral, and skin physiology, Gene polymorphism, General Medicine, Hepatitis A, Middle Aged, Prognosis, Female, Chinese population, lcsh:Medicine (General), Adult, Risk, China, medicine.medical_specialty, Immunology, Biophysics, Ocean Engineering, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Mitochondrial Proteins, Young Adult, 03 medical and health sciences, Asian People, Ammonia, Internal medicine, Humans, Genetic Predisposition to Disease, Lactic Acid, Risk factor, Survival rate, Survival analysis, business.industry, Haplotype, Case-control study, Biomedical Sciences, Cell Biology, Liver Failure, Acute, Survival Analysis, MFN2, 030104 developmental biology, lcsh:Biology (General), Case-Control Studies, business, 030217 neurology & neurosurgery, Acute liver failure |
| الوصف: | This study aimed to determine the role of mitofusin 2 (MFN2) gene polymorphisms in the risk and prognosis of acute liver failure(ALF). A total of 298 blood samples were collected from 138 ALF patients (case group) and 160 healthy participants (controlgroup). Coagulation function, glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), total bilirubin(TB), blood ammonia and lactic acid (LA) were measured. The predictive evaluation of MFN2 gene polymorphisms in the riskand prognosis of ALF patients was estimated using Kaplan-Meier survival analysis, haplotype analysis, binary logistic regressionanalysis andCox regression analysis. Higher levels of GPT, GOT, TB,blood ammonia and LAwere observed in ALF patientswiththe GG genotype of rs873457 or the TT genotype of rs4846085 than in those with the CC genotype of these two SNPs. TheGTACAGC and GTGTGGC haplotypes were a protective factor and a risk factor for ALF, respectively. Blood ammonia and LAlevels were independent risk factors andtheCCgenotype ofrs873457 and theCCgenotypeofrs4846085wereprotectivefactorsfor ALF. ALF patients with the GG genotype of rs873457 or the TT genotype of rs4846085 had a lower survival rate than thosewith other genotypes of these two SNPs. The rs4846085 and rs873457 polymorphisms were both independent factors affectingtheprognosisofALF patients.MFN2genepolymorphisms(rs873457, rs2336384,rs1474868,rs4846085andrs2236055)may beassociated with ALF and the rs873457 and rs4846085 polymorphisms are correlated with the risk and prognosis of ALF.Key words: Acute liver failure; MFN2; Gene polymorphism; Risk; Prognosis; Chinese population |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff176495ec023478d1c937604c7755a7Test http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600605&lng=en&tlng=enTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ff176495ec023478d1c937604c7755a7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |