The low efficiency of dendritic cells and macrophages from mice susceptible to Paracoccidioides brasiliensis in inducing a Th1 response
| العنوان: | The low efficiency of dendritic cells and macrophages from mice susceptible to Paracoccidioides brasiliensis in inducing a Th1 response |
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| المؤلفون: | José Daniel Lopes, S.R. Almeida |
| المساهمون: | Universidade Federal de São Paulo (UNIFESP) |
| المصدر: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP Brazilian Journal of Medical and Biological Research v.34 n.4 2001 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 4, Pages: 529-537, Published: APR 2001 Brazilian Journal of Medical and Biological Research, Vol 34, Iss 4, Pp 529-537 (2001) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Antigens, Fungal, Cell division, Mice, Inbred A, Physiology, T-Lymphocytes, T cell, Immunology, Biophysics, Antigen-Presenting Cells, Spleen, Biology, Biochemistry, Fungal Proteins, Mice, paracoccidioidomycosis, medicine, Animals, Secretion, dendritic cells, General Pharmacology, Toxicology and Pharmaceutics, Antigen-presenting cell, lcsh:QH301-705.5, Th1/Th2, Glycoproteins, Paracoccidioides brasiliensis, lcsh:R5-920, Lymphokines, Macrophages, General Neuroscience, Lymphokine, Paracoccidioides, Dendritic Cells, Cell Biology, General Medicine, Th1 Cells, biology.organism_classification, Molecular biology, medicine.anatomical_structure, lcsh:Biology (General), Interleukin 12, Female, Disease Susceptibility, Paracoccidioidomycosis, lcsh:Medicine (General), Cell Division |
| الوصف: | In the present study we evaluated T cell proliferation and Th lymphokine patterns in response to gp43 from Paracoccidioides brasiliensis presented by isolated dendritic cells from susceptible and resistant mice. T cell proliferation assays showed that dendritic cells from susceptible mice were less efficient than those from resistant mice. The pattern of T cell lymphokines stimulated by dendritic cells was always Th1, although the levels of IL-2 and IFN-gamma were lower in T cell cultures from susceptible mice. To determie whether different antigen-presenting cells such as macrophages and dendritic cells stimulated different concentrations of Th1 lymphokines, the production of IFN-gamma and IL-2 was measured. It was observed that dendritic cells were more efficient than macrophages in stimulating lymphoproliferation in resistant mice. However, no significant difference was observed for IFN-gamma or IL-2 production. When cells from susceptible mice were used, macrophages were more efficient in stimulating lymphoproliferation than dendritic cells, but no difference was observed in the production of Th1 cytokine. Taken together, these results suggest the lower efficiency of dendritic cells and macrophages from B10.A mice in stimulating T cells that secrete Th1 lymphokines in vitro, an effect that may be involved in the progression of the disease in vivo. Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Microbiologia, Imunologia e Parasitologia UNIFESP, EPM, Depto. de Microbiologia, Imunologia e Parasitologia SciELO |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14959759161770c5a0c2bd5a2928f14dTest http://repositorio.unifesp.br/handle/11600/1132Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....14959759161770c5a0c2bd5a2928f14d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |