Specific alterations in plasma proteins during depressed, manic, and euthymic states of bipolar disorder
| العنوان: | Specific alterations in plasma proteins during depressed, manic, and euthymic states of bipolar disorder |
|---|---|
| المؤلفون: | Jianjun Chen, Peng Xie, Haiyang Shi, Yongtao Yang, B. Wu, Junxi Pan, L.J. Zhang, Z.W. Zhang, C.L. Huang, Y.R. Song |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 48, Iss 11, Pp 973-982 (2015) Brazilian Journal of Medical and Biological Research v.48 n.11 2015 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 48, Issue: 11, Pages: 973-982, Published: 08 SEP 2015 |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Proteomics, Gerontology, Medicine (General), Lipid Metabolism Disorder, Apolipoprotein B, Physiology, Lipid Metabolism Disorders, Biochemistry, Mass Spectrometry, Plasma, Electrophoresis, Gel, Two-Dimensional, General Pharmacology, Toxicology and Pharmaceutics, Biology (General), Databases, Protein, lcsh:QH301-705.5, education.field_of_study, lcsh:R5-920, biology, General Neuroscience, General Medicine, Apolipoprotein L1, Blood proteins, Pathophysiology, Apolipoprotein, Disease Progression, Female, Lipoproteins, HDL, lcsh:Medicine (General), Adult, medicine.medical_specialty, Carbonic Anhydrase I, Adolescent, Bipolar disorder, QH301-705.5, Immunoblotting, Immunology, Population, Biophysics, Down-Regulation, Ocean Engineering, Diagnosis, Differential, Carbonic anhydrase 1, Young Adult, R5-920, Internal medicine, medicine, Humans, Immunoprecipitation, education, Depressive Disorder, Major, Apolipoprotein A-I, business.industry, Biomedical Sciences, Proteomic, Lipid metabolism, Cell Biology, medicine.disease, Apolipoproteins, Mood, Endocrinology, lcsh:Biology (General), biology.protein, business |
| الوصف: | Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2% of the general population of different European countries. Unfortunately, there is no objective laboratory-based test to aid BD diagnosis or monitor its progression, and little is known about the molecular basis of BD. Here, we performed a comparative proteomic study to identify differentially expressed plasma proteins in various BD mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched healthy control subjects were recruited. Seven high-abundance proteins were immunodepleted in plasma samples from the 4 experimental groups, which were then subjected to proteome-wide expression profiling by two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem mass spectrometry. Proteomic results were validated by immunoblotting and bioinformatically analyzed using MetaCore. From a total of 32 proteins identified with 1.5-fold changes in expression compared with healthy controls, 16 proteins were perturbed in BD independent of mood state, while 16 proteins were specifically associated with particular BD mood states. Two mood-independent differential proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be associated with early perturbations in lipid metabolism. Moreover, down-regulation of one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be associated with early perturbations in lipid metabolism that are independent of mood state, while CA-1 may be involved in the pathophysiology of depressive episodes. |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9d2bc8997ba558db24e91ec7a488eeTest http://www.scielo.br/pdf/bjmbr/v48n11/1414-431X-bjmbr-1414-431X20154550.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bc9d2bc8997ba558db24e91ec7a488ee |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |