Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression
| العنوان: | Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression |
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| المؤلفون: | Izzo, J. G., Malhotra, U., Wu, T. T., Luthra, R., Correa, A. M., Swisher, S. G., Hofstetter, W., Chao, K. S., Mien-Chie Hung, Ajani, J. A |
| بيانات النشر: | Asia University |
| سنة النشر: | 2007 |
| المجموعة: | ASIA University, Taiwan: Instiutional Repository (ASIAIR) / 歡迎光臨亞洲大學全球資訊網 |
| الوصف: | Background: The expression of transcriptional factor nuclear factor ?B (NF-?B) in untreated esophageal cancer specimens from patients who receive preoperative chemoradiation is associated with aggressive clinical biology. We hypothesized that nuclear NF-?B would define clinical biology even when surgery is used as primary therapy. Methods: Consecutive patients who did not receive any preoperative therapy were selected. Surgical cancer specimens were examined for nuclear NF-?B and correlated with overall survival (OS) and disease-free survival (DFS). Results: One hundred twenty-three patients (stage I, 9%; stage II, 24%; stage III, 53%; stage IV, 15%) with adenocarcinoma who underwent surgery as primary therapy were analyzed. Most patients were men (90%) and the median age was 63 years. For all 123 patients, the median DFS was 21 months and the median OS was 28 months. Nuclear NF-?B was associated with shortened DFS (P = 0.001) in 123 patients but also in stage II (P = 0.03) and stage III (P = 0.04). Nuclear NF-?B was associated with shortened OS (P = 0.002) in 123 patients and in stage II (P = 0.04) and showed trend in stage III (P = 0.17). Numbers are too small for stages I and IV. In multivariate models, nuclear NF-?B was an independent predictor for both DFS and OS (P = 0.005 and P = 0.01). Conclusions: Our data are the first to show that NF-?B status significantly correlates with DFS and OS for patients with esophageal adenocarcinoma undergoing surgery as primary therapy. NF-?B is an independent prognosticator of outcome, even for individual stages (e.g., stages II and III). More comprehensive molecular studies could help the design of strategies to individualize therapy of esophageal adenocarcinoma |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | 114 bytes; application/octet-stream |
| اللغة: | English |
| العلاقة: | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 16(6):1200-1205; http://asiair.asia.edu.tw/ir/handle/310904400/4587Test; http://asiair.asia.edu.tw/ir/bitstream/310904400/4587/1Test/; http://asiair.asia.edu.tw/ir/bitstream/310904400/4587/2/310904400-4587Test .doc |
| الإتاحة: | http://asiair.asia.edu.tw/ir/handle/310904400/4587Test http://asiair.asia.edu.tw/ir/bitstream/310904400/4587/1Test/ http://asiair.asia.edu.tw/ir/bitstream/310904400/4587/2/310904400-4587Test .doc |
| رقم الانضمام: | edsbas.E15B2E4E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |