التفاصيل البيبلوغرافية
| العنوان: |
Synthesis of new heterocycle-based selenoamides as potent cytotoxic agents. |
| المؤلفون: |
García-López, J. G.1, Gutiérrez-Hernández, A. I.2, Toscano, R. A.2, Ramírez-Apan, M. T.2, Terrón, J. A.1, Ortega-Alfaro, M. C.3, López-Cortés, J. G.2 jglcvdw@unam.mx |
| المصدر: |
ARKIVOC: Online Journal of Organic Chemistry. 2021, Vol. 2021, p13-24. 12p. |
| مصطلحات موضوعية: |
*CELL lines, *MOLECULAR structure, *SMALL molecules, *X-ray diffraction |
| مستخلص: |
We report the synthesis of a new series of aryl- and heteroaryl (hydroxy)ethyl selenoamides, in a two-step, one-pot sequence based on the aminolysis/selenative demetalation of Fischer ethoxycarbene complexes, in good to excellent global yields, as small cytotoxic molecules. The molecular structure of a 2-thienyl based selenoamide was confirmed by single-crystal X-Ray diffraction analysis. In vitro analysis against different human cancer (HCT-15, U251 and PC-3) and human T-lymphocyte (MT2) cell lines revealed that the 2-thienyl based selenoamide can be considered a potent and selective compound against the human prostatic adenocarcinoma (PC-3) cell line with an IC50 value of 14.5 µM. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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