دورية أكاديمية
Haemolytic crisis induced by rasburicase administration revealing G-6-PD deficiency
| العنوان: | Haemolytic crisis induced by rasburicase administration revealing G-6-PD deficiency |
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| المؤلفون: | SID, Sélim, Dugauquier, Christophe, DE PRIJCK, Bernard, BONNET, Christophe, Beguin, Yves |
| المصدر: | Belgian Journal of Hematology, 6 (2), 74-78 (2015) |
| بيانات النشر: | Ariez Medical Publishing |
| سنة النشر: | 2015 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Burkitt’s lymphoma, Glucose-6-phosphate dehydrogenase deficiency, rasburicase, Human health sciences, Hematology, Sciences de la santé humaine, Hématologie |
| الوصف: | peer reviewed ; We present a patient with Burkitt's lymphoma who suffered a severe haemolytic crisis after treatment with rasburicase. This case report underlines the high incidence of glucose-6-phosphate dehydrogenase deficiency in some ethnic groups and the importance of a detailed patient and family history before starting treatment, even in case of emergency. Glucose-6-phosphate dehydrogenase is an essential enzyme since it makes the synthesis of NADPH + H from NADP possible, which determines the reducing power (NADPH) of the cell. Every defect in this physiological process, notably glucose-6-phosphate dehydrogenase deficiency, may thus result simultaneously with the use of rasburicase in acute or chronic haemolysis according to the importance of the deficiency. Management is based on stopping the incriminated drug and on supportive therapy consisting of administering packed red blood cells if the anaemia is poorly tolerated. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2033-3749 |
| العلاقة: | urn:issn:2033-3749; https://orbi.uliege.be/handle/2268/194566Test; info:hdl:2268/194566; https://orbi.uliege.be/bitstream/2268/194566/1/347.pdfTest |
| الإتاحة: | https://orbi.uliege.be/handle/2268/194566Test https://orbi.uliege.be/bitstream/2268/194566/1/347.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5051305C |
| قاعدة البيانات: | BASE |
| تدمد: | 20333749 |
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