Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury: a CENTER-TBI study
| العنوان: | Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury: a CENTER-TBI study |
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| المؤلفون: | Riemann, Lennart, Beqiri, Erta, Smielewski, Peter, Czosnyka, Marek, Stocchetti, Nino, Sakowitz, Oliver, Zweckberger, Klaus, Unterberg, Andreas, Younsi, Alexander, Anke, Audny, Beer, Ronny, Bellander, Bo-Michael, Buki, Andras, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Czeiter, Endre, Depreitere, Bart, Eapen, George, Frisvold, Shirin, Helbok, Raimund, Jankowski, Stefan, Kondziella, Daniel, Koskinen, Lars-Owe, Meyfroidt, Geert, Moeller, Kirsten, Nelson, David, Piippo-Karjalainen, Anna, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rhodes, Jonathan, Rocka, Saulius, Rossaint, Rolf, Sahuquillo, Juan, Stevanovic, Ana, Sundström, Nina, Takala, Riikka, Tamosuitis, Tomas, Tenovuo, Olli, Vajkoczy, Peter, Vargiolu, Alessia, Vilcinis, Rimantas, Wolf, Stefan |
| المساهمون: | Younsi, Alexander [0000-0002-8218-9243], Apollo - University of Cambridge Repository, Ragauskas, Arminas, Rocka, Saulius, Tamosuitis, Tomas, Vilcinis, Rimantas, „Springer' grupė, Ročka, Saulius, Tamošuitis, Tomas, Riemann, L, Beqiri, E, Smielewski, P, Czosnyka, M, Stocchetti, N, Sakowitz, O, Zweckberger, K, Unterberg, A, Younsi, A, Anke, A, Beer, R, Bellander, B, Buki, A, Chevallard, G, Chieregato, A, Citerio, G, Czeiter, E, Depreitere, B, Eapen, G, Frisvold, S, Helbok, R, Jankowski, S, Kondziella, D, Koskinen, L, Meyfroidt, G, Moeller, K, Nelson, D, Piippo-Karjalainen, A, Radoi, A, Ragauskas, A, Raj, R, Rhodes, J, Rocka, S, Rossaint, R, Sahuquillo, J, Stevanovic, A, Sundstrom, N, Takala, R, Tamosuitis, T, Tenovuo, O, Vajkoczy, P, Vargiolu, A, Vilcinis, R, Wolf, S |
| المصدر: | Critical Care Critical care, London : BioMed Central, 2020, vol. 24, iss. 1, art. no. 266, p. 1-12 Critical Care, Vol 24, Iss 1, Pp 1-12 (2020) Riemann, L, Beqiri, E, Smielewski, P, Czosnyka, M, Stocchetti, N, Sakowitz, O, Zweckberger, K, Unterberg, A, Younsi, A, Anke, A, Beer, R, Bellander, B M, Buki, A, Chevallard, G, Chieregato, A, Citerio, G, Czeiter, E, Depreitere, B, Eapen, G, Frisvold, S, Helbok, R, Jankowski, S, Kondziella, D, Koskinen, L O, Meyfroidt, G, Moeller, K, Nelson, D, Piippo-Karjalainen, A, Radoi, A, Ragauskas, A, Raj, R, Rhodes, J, Rocka, S, Rossaint, R, Sahuquillo, J, Stevanovic, A, Sundström, N, Takala, R, Tamosuitis, T, Tenovuo, O, Vajkoczy, P, Vargiolu, A, Vilcinis, R & Wolf, S 2020, ' Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury : A CENTER-TBI study ', Critical Care, vol. 24, no. 1, 266 . https://doi.org/10.1186/s13054-020-02974-8Test |
| بيانات النشر: | Apollo - University of Cambridge Repository, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Multivariate statistics, Multivariate analysis, Neurologi, INTRACRANIAL-PRESSURE, Traumatic brain injury, Critical Care and Intensive Care Medicine, Cerebral autoregulation, 03 medical and health sciences, 0302 clinical medicine, Critical Care Medicine, General & Internal Medicine, Internal medicine, Brain Injuries, Traumatic, MANAGEMENT, medicine, Humans, Cerebrovascular reactivity, 030212 general & internal medicine, Cerebral perfusion pressure, Aged, Retrospective Studies, Intracranial pressure, CPPopt, Science & Technology, business.industry, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Univariate, lcsh:RC86-88.9, Middle Aged, medicine.disease, Intensive Care Units, Blood pressure, Neurology, Cerebrovascular Circulation, Cardiology, Female, business, Life Sciences & Biomedicine, 030217 neurology & neurosurgery |
| الوصف: | Background After traumatic brain injury (TBI), brain tissue can be further damaged when cerebral autoregulation is impaired. Managing cerebral perfusion pressure (CPP) according to computed “optimal CPP” values based on cerebrovascular reactivity indices might contribute to preventing such secondary injuries. In this study, we examined the discriminative value of a low-resolution long pressure reactivity index (LPRx) and its derived “optimal CPP” in comparison to the well-established high-resolution pressure reactivity index (PRx). Methods Using the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study dataset, the association of LPRx (correlation between 1-min averages of intracranial pressure and arterial blood pressure over a moving time frame of 20 min) and PRx (correlation between 10-s averages of intracranial pressure and arterial blood pressure over a moving time frame of 5 min) to outcome was assessed and compared using univariate and multivariate regression analysis. “Optimal CPP” values were calculated using a multi-window algorithm that was based on either LPRx or PRx, and their discriminative ability was compared. Results LPRx and PRx were both significant predictors of mortality in univariate and multivariate regression analysis, but PRx displayed a higher discriminative ability. Similarly, deviations of actual CPP from “optimal CPP” values calculated from each index were significantly associated with outcome in univariate and multivariate analysis. “Optimal CPP” based on PRx, however, trended towards more precise predictions. Conclusions LPRx and its derived “optimal CPP” which are based on low-resolution data were significantly associated with outcome after TBI. However, they did not reach the discriminative ability of the high-resolution PRx and its derived “optimal CPP.” Nevertheless, LPRx might still be an interesting tool to assess cerebrovascular reactivity in centers without high-resolution signal monitoring. Trial registration ClinicalTrials.gov Identifier: NCT02210221. First submitted July 29, 2014. First posted August 6, 2014. |
| وصف الملف: | application/pdf; text/xml; Electronic |
| تدمد: | 1364-8535 1466-609X |
| DOI: | 10.17863/cam.53476 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad4531a1057056dc08081447cbabd42Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9ad4531a1057056dc08081447cbabd42 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13648535 1466609X |
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| DOI: | 10.17863/cam.53476 |