The management of diabetic ketoacidosis at a rural regional hospital in KwaZulu-Natal
| العنوان: | The management of diabetic ketoacidosis at a rural regional hospital in KwaZulu-Natal |
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| المؤلفون: | Mergan Naidoo, Nontobeko F.M. Ndebele |
| المصدر: | African Journal of Primary Health Care & Family Medicine African Journal of Primary Health Care & Family Medicine, Volume: 10, Issue: 1, Pages: 1-6, Published: 2018 African Journal of Primary Health Care & Family Medicine, Vol 10, Iss 1, Pp e1-e6 (2018) |
| بيانات النشر: | AOSIS, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Pediatrics, endocrine system diseases, lcsh:Medicine, Comorbidity, outcomes, South Africa, 0302 clinical medicine, Risk Factors, rural setting, Prevalence, 030212 general & internal medicine, Child, Original Research, Aged, 80 and over, lcsh:Public aspects of medicine, Mortality rate, Age Factors, General Medicine, Middle Aged, Female, Family Practice, Adult, medicine.medical_specialty, Diabetic ketoacidosis, Adolescent, 030209 endocrinology & metabolism, Diabetic Ketoacidosis, Medication Adherence, 03 medical and health sciences, Young Adult, Diabetes mellitus, medicine, Humans, Aged, Retrospective Studies, Type 1 diabetes, business.industry, lcsh:R, Public Health, Environmental and Occupational Health, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, lcsh:RA1-1270, Emergency department, Length of Stay, medicine.disease, Ketoacidosis, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, business |
| الوصف: | Background: Diabetic ketoacidosis (DKA) is a biochemical triad of hyperglycaemia, ketoacidosis and ketonaemia and one of the potentially life-threatening acute metabolic complications of diabetes mellitus. This study aimed at describing the clinical profile of patients presenting with DKA to a busy rural regional hospital in KwaZulu-Natal.Methods: A retrospective review of clinical notes of patients presenting with DKA to the Emergency Department was performed over a 10-month period. Data included patients’ demographic profile, clinical presentation, precipitating factors, comorbidities, biochemical profile, length of hospital stay and outcome.Results: One hundred and five black South African patients above the age of 12 years were included in the study. Sixty-four (60.95%) patients had type 1 diabetes mellitus (T1DM) and 41 (39.05%) patients had type 2 diabetes mellitus (T2DM). Patients with T2DM were significantly older than those with T1DM (52.1 ± 12.4 years vs. 24.4 ± 9.5 years, p < 0.0001). The acute precipitant was identified in 68 (64.76%) cases with the commonest precipitant in T1DM patients being poor adherence to treatment, whereas in T2DM, the most common precipitant was infection. Nausea and vomiting were the most common presenting symptoms with the majority of patients presenting with non-specific symptoms. Fifty-seven (54.29%) cases had pre-existing comorbidities, with higher prevalence in T2DM than T1DM patients. Glycated haemoglobin was severely elevated in the majority of patients. Patients remained hospitalised for an average of 8.9 ± 7.5 days. The mortality rate was 17.14%, and 12 of the 18 deaths occurred in patients with T2DM.Conclusion: The prevalence of DKA was higher in patients with T1DM and those with pre-existing comorbidities. The mortality rate remains alarmingly high in older patients with T2DM. |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 2071-2936 2071-2928 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24dec1bbf9b02e88d2fd62dd2654f68Test http://europepmc.org/articles/PMC5913763Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d24dec1bbf9b02e88d2fd62dd2654f68 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20712936 20712928 |
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