Relative Biological Effectiveness Values of Spot-scanning Proton Beam Therapy at Shonan Kamakura General Hospital
| العنوان: | Relative Biological Effectiveness Values of Spot-scanning Proton Beam Therapy at Shonan Kamakura General Hospital |
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| المؤلفون: | SHIBA, SHINTARO, YAMANAKA, MASASHI, MATSUMOTO, KAZUKI, YAMANO, AKIHIRO, SHIMO, TAKAHIRO, SUZUKI, SHUNSUKE, YAGIHASHI, TAKAYUKI, NITTA, KAZUNORI, OHNO, TATSUYA, TOKUUYE, KOICHI, OMURA, MOTOKO |
| المصدر: | In Vivo |
| بيانات النشر: | Anticancer Research USA Inc., 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Pharmacology, Cancer Research, General Biochemistry, Genetics and Molecular Biology, Research Article |
| الوصف: | Background/Aim: This study aimed to confirm the relative biological effectiveness (RBE) values of the proton beam therapy (PBT) system installed in Shonan Kamakura General Hospital. Materials and Methods: Clonogenic cell-survival assays were performed with a human salivary gland (HSG) cell line, a human tongue squamous-cell carcinoma cell line (SAS), and a human osteosarcoma cell line (MG-63). Cells were irradiated with proton beams and X-rays with different doses (1.8, 3.6, 5.5, and 7.3 Gy for proton beams, and 2, 4, 6, and 8 Gy for X-rays). Proton beam irradiation used spot-scanning methods and three different depths (at the proximal, center, and distal sides of the spread-out Bragg peak). RBE values were obtained from a comparison of the dose that resulted in a surviving fraction of 10% (D(10)). Results: D(10) of proton beams at the proximal, center, and distal sides and X-rays in HSG were 4.71, 4.71, 4.51, and 5.25 Gy, respectively; those in SAS were 5.08, 5.04, 5.01, and 5.59 Gy, respectively; and those in MG-63 were 5.36, 5.42, 5.12, and 6.06 Gy, respectively. The RBE(10) values at the proximal, center, and distal sides in HSG were 1.11, 1.11, and 1.16 respectively; those in SAS were 1.10, 1.11, and 1.12, respectively; and those in MG-63 were 1.13, 1.12, and 1.18, respectively. Conclusion: RBE(10) values of 1.10-1.18 were confirmed by in vitro experiments using the PBT system. These results are considered acceptable for clinical use in terms of therapeutic efficacy and safety. |
| تدمد: | 1791-7549 0258-851X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eddc2cf100b78299bf74a52745895dfdTest https://doi.org/10.21873/invivo.13175Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....eddc2cf100b78299bf74a52745895dfd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17917549 0258851X |
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