The Cell Wall of the Human Fungal Pathogen Aspergillus fumigatus: Biosynthesis, Organization, Immune Response, and Virulence
| العنوان: | The Cell Wall of the Human Fungal Pathogen Aspergillus fumigatus: Biosynthesis, Organization, Immune Response, and Virulence |
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| المؤلفون: | Georgios Chamilos, Anne Beauvais, Jean-Paul Latgé |
| المصدر: | Annual Review of Microbiology. 71:99-116 |
| بيانات النشر: | Annual Reviews, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Cell, Microbiology, Aspergillus fumigatus, Cell wall, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cell Wall, Polysaccharides, Organelle, medicine, Aspergillosis, Humans, Cellular localization, Aspergillus, Virulence, biology, biology.organism_classification, Transmembrane protein, 030104 developmental biology, medicine.anatomical_structure, Host-Pathogen Interactions, 030215 immunology |
| الوصف: | More than 90% of the cell wall of the filamentous fungus Aspergillus fumigatus comprises polysaccharides. Biosynthesis of the cell wall polysaccharides is under the control of three types of enzymes: transmembrane synthases, which are anchored to the plasma membrane and use nucleotide sugars as substrates, and cell wall–associated transglycosidases and glycosyl hydrolases, which are responsible for remodeling the de novo synthesized polysaccharides and establishing the three-dimensional structure of the cell wall. For years, the cell wall was considered an inert exoskeleton of the fungal cell. The cell wall is now recognized as a living organelle, since the composition and cellular localization of the different constitutive cell wall components (especially of the outer layers) vary when the fungus senses changes in the external environment. The cell wall plays a major role during infection. The recognition of the fungal cell wall by the host is essential in the initiation of the immune response. The interactions between the different pattern-recognition receptors (PRRs) and cell wall pathogen-associated molecular patterns (PAMPs) orientate the host response toward either fungal death or growth, which would then lead to disease development. Understanding the molecular determinants of the interplay between the cell wall and host immunity is fundamental to combatting Aspergillus diseases. |
| تدمد: | 1545-3251 0066-4227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63de916e0949b3fb58d3aeee51881ec4Test https://doi.org/10.1146/annurev-micro-030117-020406Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....63de916e0949b3fb58d3aeee51881ec4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15453251 00664227 |
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