Diuretics: Sites and Mechanisms of Action
| العنوان: | Diuretics: Sites and Mechanisms of Action |
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| المؤلفون: | H R Jacobson, J P Kokko |
| المصدر: | Annual Review of Pharmacology and Toxicology. 16:201-214 |
| بيانات النشر: | Annual Reviews, 1976. |
| سنة النشر: | 1976 |
| مصطلحات موضوعية: | Organomercury Compounds, medicine.medical_treatment, Nephron, Toxicology, Bioinformatics, Dogs, medicine, Animals, Humans, Carbonic Anhydrase Inhibitors, Diuretics, Adverse effect, Pharmacology, Sulfonamides, Binding Sites, Water transport, business.industry, Biological Transport, Diuretics, Osmotic, RENAL PHARMACOLOGY, Rats, medicine.anatomical_structure, Action (philosophy), Renal physiology, Potassium, Rabbits, Anura, Diuretic, business |
| الوصف: | One of the most powerful and frequently used clinical tools in the physician's pharmaceutical armamentarium is the class of diuretic drugs. The list of available and currently investigated agents is quite long. This review examines the renal pharmacology of these drugs with respect to their sites and mechanisms of action. First we outline normal renal physiology with respect to the major locations and mechanisms of salt and water transport along the nephron as determined largely by micropuncture and in vitro microperfusion. Then we examine each class of diuretic agents with respect to what is presently known about their specific alteration of the normal renal physiology that results in their beneficial and, at times, adverse effects. |
| تدمد: | 1545-4304 0362-1642 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e7fc02d6d8af60c0393673ddb7cd7aTest https://doi.org/10.1146/annurev.pa.16.040176.001221Test |
| رقم الانضمام: | edsair.doi.dedup.....04e7fc02d6d8af60c0393673ddb7cd7a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15454304 03621642 |
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