Progress and Prospects for Stem Cell Engineering
| العنوان: | Progress and Prospects for Stem Cell Engineering |
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| المؤلفون: | Joseph Peltier, David V. Schaffer, Albert J. Keung, Randolph S. Ashton |
| المصدر: | Annual Review of Chemical and Biomolecular Engineering. 2:479-502 |
| بيانات النشر: | Annual Reviews, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Cell type, Cell signaling, General Chemical Engineering, Cellular differentiation, Cell- and Tissue-Based Therapy, Cell fate determination, Biology, Article, Body of knowledge, Animals, Humans, Cell Engineering, Renewable Energy, Sustainability and the Environment, business.industry, Stem Cells, Cell Differentiation, General Chemistry, Microarray Analysis, High-Throughput Screening Assays, Biotechnology, Stem cell fate, Models, Chemical, Biochemical engineering, Stem cell, business, Intracellular |
| الوصف: | Stem cells offer tremendous biomedical potential owing to their abilities to self-renew and differentiate into cell types of multiple adult tissues. Researchers and engineers have increasingly developed novel discovery technologies, theoretical approaches, and cell culture systems to investigate microenvironmental cues and cellular signaling events that control stem cell fate. Many of these technologies facilitate high-throughput investigation of microenvironmental signals and the intracellular signaling networks and machinery processing those signals into cell fate decisions. As our aggregate empirical knowledge of stem cell regulation grows, theoretical modeling with systems and computational biology methods has and will continue to be important for developing our ability to analyze and extract important conceptual features of stem cell regulation from complex data. Based on this body of knowledge, stem cell engineers will continue to develop technologies that predictably control stem cell fate with the ultimate goal of being able to accurately and economically scale up these systems for clinical-grade production of stem cell therapeutics. |
| تدمد: | 1947-5446 1947-5438 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c998dbc83a1e73066b5fcdfb9b9ae9Test https://doi.org/10.1146/annurev-chembioeng-061010-114105Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....05c998dbc83a1e73066b5fcdfb9b9ae9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19475446 19475438 |
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