Axon Growth and Guidance: Receptor Regulation and Signal Transduction
| العنوان: | Axon Growth and Guidance: Receptor Regulation and Signal Transduction |
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| المؤلفون: | Michael P. O'Donnell, Greg J. Bashaw, Rebecca K. Chance |
| المصدر: | Annual Review of Neuroscience. 32:383-412 |
| بيانات النشر: | Annual Reviews, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Nervous system, Cell signaling, Cellular differentiation, Growth Cones, Cell Communication, Receptors, Nerve Growth Factor, Biology, Nervous System, Article, Neural Pathways, medicine, Animals, Humans, Nerve Growth Factors, Axon, Growth cone, Receptor, Body Patterning, General Neuroscience, Cell Differentiation, Cell biology, medicine.anatomical_structure, Cues, Signal transduction, Neuroscience, Function (biology), Signal Transduction |
| الوصف: | The development of precise connectivity patterns during the establishment of the nervous system depends on the regulated action of diverse, conserved families of guidance cues and their neuronal receptors. Determining how these signaling pathways function to regulate axon growth and guidance is fundamentally important to understanding wiring specificity in the nervous system and will undoubtedly shed light on many neural developmental disorders. Considerable progress has been made in defining the mechanisms that regulate the correct spatial and temporal distribution of guidance receptors and how these receptors in turn signal to the growth cone cytoskeleton to control steering decisions. This review focuses on recent advances in our understanding of the mechanisms mediating growth cone guidance with a particular emphasis on the control of guidance receptor regulation and signaling. |
| تدمد: | 1545-4126 0147-006X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bf0851e3851e81def238af8ee41844Test https://doi.org/10.1146/annurev.neuro.051508.135614Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....36bf0851e3851e81def238af8ee41844 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15454126 0147006X |
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