التفاصيل البيبلوغرافية
| العنوان: |
Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: Lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial |
| المؤلفون: |
Houssiau, Frédéric A, Vasconcelos, Carlos, D'Cruz, David, Sebastiani, Gian Domenico, de Ramon Garrido, Enrique, Danieli, Maria Giovanna, Abramovicz, Daniel, Blockmans, Daniel Engelbert, Mathieu, Alessandro, Direskeneli, Haner, Galeazzi, Mauro, Gül, Ahmet, Levy, Yair, Petera, Peter, Popovic, Rajko, Petrovic, Radmila, Sinico, Renato Alberto, Cattaneo, Roberto, Font, Josep, Depresseux, Geneviève, Cosyns, Jean-Pierre, Cervera, Ricard |
| بيانات النشر: |
Annals of the Rheumatic Diseases |
| سنة النشر: |
2004 |
| المجموعة: |
KU Leuven: Lirias |
| الوصف: |
Background: In a prospective trial (the Euro-Lupus Nephritis Trial [ELNT]), we randomly assigned 90 lupus patients with proliferative glomerulonephritis to a high-dose (HD) intravenous (IV) cyclophosphamide (CYC) regimen (6 monthly pulses and 2 quarterly pulses; doses increased according to white blood cell count nadir) or a low-dose (LD) IV CYC regimen (6 fortnightly pulses at a fixed dose of 500 mg), each of which was followed by azathioprine (AZA). After a median of 41.3 months (M), we did not observe a different efficacy between the two regimens (Houssiau et al. A&R 2002; 46: 2121). The purpose of the current analysis is to extend the follow-up and to identify pronostic factors.Methods: Follow-up data were collected from all patients randomized in the ELNT, except 5 who were lost to follow-up. Survival curves were derived using the Kaplan-Meier (KM) method. Patients were classified in two groups (poor or good long-term renal outcome) according to the development (or not) of permanent renal impairment at last follow-up (defined as a serum creatinine value repeatedly ≥ 1.4 mg/dl). Their baseline characteristics and early response to therapy were compared.Results: After a mean (± SD) follow-up of 68 ± 18 M, the KM analyses indicated that there was no significantly greater cumulative probability of end-stage renal disease (ESRD), doubling of serum creatinine (DSC) or death in patients given a LD IV CYC regimen. At long-term follow-up, 18 patients (8 LD and 10 HD) had suffered from permanent renal impairment (ESRD, DSC or impaired renal function but without reaching DSC). Their baseline mean serum creatinine was significantly higher (p = 0.03) than that measured in patients with good long-term renal outcome. Interestingly, their initial response after 3 M and 6 M of therapy was much less favourable. Thus, mean (g ± SD) 24-h proteinuria, dropped from 3.03 ± 2.49 at baseline to 1.48 ± 1.28 at 3 M and to 1.15 ± 1.41 at 6 M in patients with good renal outcome, while it remained high in the poor renal outcome ... |
| نوع الوثيقة: |
conference object |
| اللغة: |
English |
| العلاقة: |
vol:63 issue:11 pages:111-112; EULAR 2004 location:Berlin, Germany date:9-12 June 2004; https://lirias.kuleuven.be/handle/123456789/182433Test |
| الإتاحة: |
https://lirias.kuleuven.be/handle/123456789/182433Test |
| رقم الانضمام: |
edsbas.2F673F5C |
| قاعدة البيانات: |
BASE |
