التفاصيل البيبلوغرافية
| العنوان: |
Anti-SARS-CoV-2 antibodies persistence after natural infection: a repeated serosurvey in Northern Italy: COVID-19 IgG longevity and neutralization |
| المؤلفون: |
Fedele, Giorgio, Stefanelli, Paola, Bella, Antonino, Fiore, Stefano, Pancheri, Serena, Benedetti, Eleonora, Fabiani, Concetta, Leone, Pasqualina, Vacca, Paola, Schiavoni, Ilaria, Neri, Arianna, Carannante, Anna, Simmaco, Maurizio, Santino, Iolanda, Zuccali, Maria Grazia, Bizzarri, Giancarlo, Magnoni, Rosa, Benetollo, Pier Paolo, Brusaferro, Silvio, Rezza, Giovanni, Ferro, Antonio |
| المصدر: |
Annali dell'Istituto Superiore di Sanità; Vol. 57 No. 4 (2021); 265-271 ; 2384-8553 ; 0021-2571 |
| بيانات النشر: |
Annali dell'Istituto Superiore di Sanità |
| سنة النشر: |
2021 |
| المجموعة: |
Annali dell'Istituto Superiore di Sanità |
| الوصف: |
Introduction. To evaluate the decline of antibodies induced by SARS-CoV-2 infection, the individuals resident in 5 municipalities of the Autonomous Province of Trento, Northern Italy, who resulted IgG positive for anti-SARS-CoV-2 nucleocapsid (NC) in May 2020, were tested four months later.Methods. Anti-SARS-CoV-2 NC antibodies were detected using the Abbott SARSCoV-2 IgG assay. Samples that gave a negative result were re-tested using the Liaison SARS-CoV-2 IgG assay to assess anti-spike (S) S1/S2 antibodies. The fifty-percent tissue culture infective dose (TCID50) neutralizing assay was performed on a subgroup of formerly positive sera. Statistical analysis was performed by STATA version 16.1 (STATA Corp., College Station, Texas, USA).Results. Overall, 480 out of 1159 participants became seronegative for anti-NC IgG antibodies. Age above 70 years and cough were associated with persistent anti-NC IgG levels. Most anti-NC IgG negative sera were positive for anti-S IgG (77.9%). The neutralization assay showed high concordance with anti-S antibodies positivity.Conclusion. In conclusion, a decline of anti-NC IgG values was recorded four months after the first evaluation. A high proportion of anti-NC seronegative individuals were positive for anti-spike IgG antibodies, which appear to persist longer and to better correlate with neutralization activity. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
https://annali.iss.it/index.php/anna/article/view/1394/791Test; https://annali.iss.it/index.php/anna/article/view/1394Test |
| الإتاحة: |
https://annali.iss.it/index.php/anna/article/view/1394Test |
| حقوق: |
Copyright (c) 2021 Istituto Superiore di Sanità ; http://creativecommons.org/licenses/by-nc-nd/4.0Test |
| رقم الانضمام: |
edsbas.31D0FBFA |
| قاعدة البيانات: |
BASE |
