Bedside prediction of mortality from bacteremic sepsis. A dynamic analysis of ICU patients
| العنوان: | Bedside prediction of mortality from bacteremic sepsis. A dynamic analysis of ICU patients |
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| المؤلفون: | Ning Li, Didier Pittet, B. Thievent, Peter M. Suter, Richard P. Wenzel, Raymond Auckenthaler |
| المصدر: | American Journal of Respiratory and Critical Care Medicine, Vol. 153, No 2 (1996) pp. 684-693 |
| بيانات النشر: | American Thoracic Society, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Male, Pulmonary and Respiratory Medicine, Artificial ventilation, medicine.medical_specialty, medicine.medical_treatment, Bacteremia, Critical Care and Intensive Care Medicine, Body Temperature, law.invention, Sepsis, Risk Factors, law, Internal medicine, Severity of illness, Case fatality rate, Confidence Intervals, Odds Ratio, medicine, Humans, ddc:576.5, Hospital Mortality, Intensive care medicine, APACHE, Aged, Mechanical ventilation, business.industry, Bacteremia/ mortality/therapy, Odds ratio, Middle Aged, Prognosis, medicine.disease, Apache, Respiration, Artificial, Intensive care unit, Anti-Bacterial Agents, Anti-Bacterial Agents/therapeutic use, Intensive Care Units, Female, business |
| الوصف: | The prognosis in patients with sepsis depends on severity of acute illness, underlying chronic diseases, and complications associated with infection. Adjusting for these factors is essential for evaluation of new therapies. The purpose of the present study was to determine variables readily identifiable at the bedside that predict mortality in intensive care unit (ICU) patients with sepsis and positive blood cultures. For a 5-yr period, all patients of a surgical ICU presenting with positive blood cultures and sepsis were systematically analyzed for clinical variables and organ dysfunctions at the day of onset of sepsis and bacteremia and during the subsequent clinical course. The prognostic value of these variables was determined using logistic regression procedures. Of the 5,457 admissions to the ICU, 176 patients developed sepsis with positive blood cultures (3.2 per 100 admissions). The fatality rate was 35% at 28 days after the onset of sepsis; in-hospital mortality was 43%. Independent predictors of mortality at onset of sepsis were previous antibiotic therapy (odds ratio [OR], 2.40; 95% confidence interval [CI95], 1.59 to 3.62; p = 0.034), hypothermia (OR, 1.43; CI95, 1.04 to 2.44; p = 0.030), requirement for mechanical ventilation (OR, 2.97; CI95, 1.96 to 4.51; p = 0.009), and onset-of-sepsis APACHE II score (OR, 1.21; CI95, 1.13 to 1.29; p < 0.001). Vital organ dysfunctions developing after the onset of sepsis influenced outcome markedly. The best two independent prognostic factors were the APACHE II score at the onset of sepsis (OR, 1.13 per unit; CI95, 1.08 to 1.17; p = 0.0016) and the number of organ dysfunctions developing thereafter (OR, 2.39; CI95, 2.02 to 2.82; p < 0.001). In ICU patients with sepsis and positive blood cultures, outcome can be predicted by the severity of illness at onset of sepsis and the number of vital organ dysfunctions developing subsequently. These variables are easily assessed at the bedside and should be included in the evaluation of new therapeutic strategies. |
| تدمد: | 1535-4970 1073-449X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5188d32eadcd693f0e9293e05f0a259Test https://doi.org/10.1164/ajrccm.153.2.8564118Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b5188d32eadcd693f0e9293e05f0a259 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354970 1073449X |
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