Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness Requires Interleukin-5 but Not Immunoglobulin E or B Lymphocytes
| العنوان: | Development of Eosinophilic Airway Inflammation and Airway Hyperresponsiveness Requires Interleukin-5 but Not Immunoglobulin E or B Lymphocytes |
|---|---|
| المؤلفون: | Jürgen Schwarze, Erwin W. Gelfand, Charles G. Irvin, Katsuyuki Takeda, Anthony T. Vella, Eckard Hamelmann |
| المصدر: | American Journal of Respiratory Cell and Molecular Biology. 21:480-489 |
| بيانات النشر: | American Thoracic Society, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, biology, business.industry, medicine.medical_treatment, Clinical Biochemistry, Cell Biology, respiratory system, Eosinophil, Immunoglobulin E, respiratory tract diseases, Allergic sensitization, Ovalbumin, medicine.anatomical_structure, Cytokine, Immunology, Eosinophil activation, biology.protein, medicine, Methacholine, business, Molecular Biology, Interleukin 5, medicine.drug |
| الوصف: | We previously defined a role for B cells and allergen-specific immunoglobulins in the development of allergic sensitization, airway inflammation, and airway hyperresponsiveness (AHR), using a 10-d protocol in which allergen exposure occurred exclusively via the airways, without adjuvant. In the present protocol, normal and B-cell–deficient (μMt−/−) mice were sensitized intraperitoneally to ovalbumin (OVA) and challenged with OVA via the airways in order to examine the requirements for AHR with this protocol. T-cell activation (antigen-specific proliferative responses and Th2-type cytokine production) and eosinophil infiltration in the peribronchial regions of the airways, with signs of eosinophil activation and degranulation, occurred in both experimental groups. In contrast to the 10-d protocol, increased in vivo airway responsiveness to methacholine and in vitro tracheal smooth-muscle responses to electrical field stimulation were observed in both normal and B-cell–deficient mice, and these responses we... |
| تدمد: | 1535-4989 1044-1549 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::9eadaae484bf1b9b095f4b4c5fe90eccTest https://doi.org/10.1165/ajrcmb.21.4.3659Test |
| رقم الانضمام: | edsair.doi...........9eadaae484bf1b9b095f4b4c5fe90ecc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354989 10441549 |
|---|