Polymorphisms in Toll-Like Receptor 4 Are Not Associated with Asthma or Atopy-related Phenotypes
| العنوان: | Polymorphisms in Toll-Like Receptor 4 Are Not Associated with Asthma or Atopy-related Phenotypes |
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| المؤلفون: | Benjamin A. Raby, Fernando D. Martinez, Yannick Renaud, David J. Kwiatkowski, Walter T. Klimecki, Christoph Lange, Catherine Laprise, Celia M. T. Greenwood, Janet Faith, Donata Vercelli, Thomas J. Hudson, Ross Lazarus, Lyle J. Palmer, Edwin K. Silverman, Katherine M. Weiland, Mathieu Lemire, Scott T. Weiss |
| المصدر: | American Journal of Respiratory and Critical Care Medicine. 166:1449-1456 |
| بيانات النشر: | American Thoracic Society, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Population, Receptors, Cell Surface, Locus (genetics), Single-nucleotide polymorphism, Biology, Critical Care and Intensive Care Medicine, Linkage Disequilibrium, Cohort Studies, Atopy, Genetic variation, Hypersensitivity, medicine, Drosophila Proteins, Humans, education, Genetic association, Genetics, education.field_of_study, Genetic diversity, Membrane Glycoproteins, Polymorphism, Genetic, Toll-Like Receptors, Chromosome Mapping, medicine.disease, Asthma, Toll-Like Receptor 4, Phenotype, Haplotypes, Immunology, Cohort |
| الوصف: | Toll-like receptor 4 (TLR4) is the principal receptor for bacterial endotoxin recognition, and functional variants in the gene confer endotoxin-hyporesponsiveness in humans. Furthermore, there is evidence that endotoxin exposure during early life is protective against the development of atopy and asthma, although this relationship remains poorly understood. It is therefore possible that genetic variation in the TLR4 locus contributes to asthma susceptibility. In this study we characterize the genetic diversity in the TLR4 locus and test for association between the common genetic variants and asthma-related phenotypes. In a cohort of 90 ethnically diverse subjects, we resequenced the TLR4 locus and identified a total of 29 single nucleotide polymorphisms. We assessed five common polymorphisms for evidence of association with asthma in two large family-based cohorts: a heterogeneous North American cohort (589 families), and a more homogenous population from northeastern Quebec, Canada (167 families). Using the transmission-disequilibrium test, we found no evidence of association for any of the polymorphisms tested, including two functional variants. Furthermore, we found no evidence for association between the TLR4 variants and four quantitative intermediate asthma- and atopy-related phenotypes. Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility. |
| تدمد: | 1535-4970 1073-449X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb5df3e7444d9e1ff9e76ceb76b6c30Test https://doi.org/10.1164/rccm.200207-634ocTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1cb5df3e7444d9e1ff9e76ceb76b6c30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354970 1073449X |
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