Interleukin-10–Secreting 'Regulatory' T Cells Induced by Glucocorticoids and β2-Agonists
| العنوان: | Interleukin-10–Secreting 'Regulatory' T Cells Induced by Glucocorticoids and β2-Agonists |
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| المؤلفون: | Emma Peek, Alexander Faith, Paul Lavender, Tak H. Lee, Catherine M. Hawrylowicz, Christopher Corrigan, David F. Richards |
| المصدر: | American Journal of Respiratory Cell and Molecular Biology. 33:105-111 |
| بيانات النشر: | American Thoracic Society, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Male, T-Lymphocytes, medicine.medical_treatment, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmacology, immune system diseases, Salmeterol Xinafoate, Fluticasone, Interleukin-13, Chemistry, Interleukin, Adrenergic beta-Agonists, Middle Aged, respiratory system, Interleukin-10, Interleukin 10, Cytokine, medicine.anatomical_structure, Cytokines, Female, Salmeterol, Glucocorticoid, medicine.drug, Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, T cell, Cell Line, Dermatitis, Atopic, Interferon-gamma, Th2 Cells, Internal medicine, medicine, Humans, Albuterol, Adrenergic beta-2 Receptor Agonists, Glucocorticoids, Molecular Biology, Dose-Response Relationship, Drug, Cell Biology, Allergens, respiratory tract diseases, Androstadienes, Endocrinology, Cell culture, Leukocytes, Mononuclear, Interleukin-5 |
| الوصف: | Greater clinical benefit in controlling the symptoms of asthma is frequently observed through combining moderate doses of inhaled glucocorticoids together with long-acting beta(2)-agonists, as compared with increasing glucocorticoid dosage alone. To address in vitro whether glucocorticoids plus beta(2)-agonists, compared with glucocorticoids alone, have greater inhibitory activity on CD4+ T cell responses to allergen, peripheral blood CD4+ T cell responses to allergen were compared in the presence or absence of the glucocorticoid fluticasone proprionate and the short- and long-acting beta(2)-agonists salbutamol and salmeterol, respectively. Fluticasone proprionate inhibited interleukin (IL)-5 and IL-13 and enhanced IL-10 synthesis in allergen-stimulated cultures in a concentration-dependent manner. Salmeterol, but not salbutamol, inhibited IL-5 and IL-13 and enhanced IL-10 synthesis in these cultures. When used in combination the two drugs demonstrated an additive effect on this pattern of cytokine production. Allergen-specific T cell lines induced in the presence of salmeterol and fluticasone proprionate inhibited IL-5 and IL-13 production by allergen-specific Th2 cell lines in an IL-10-dependent manner. Thus fluticasone proprionate and salmeterol increased IL-10 and reduced Th2 cytokine synthesis additively in allergen stimulated human CD4+ T cells. |
| تدمد: | 1535-4989 1044-1549 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c9a36f6b7b02a6756aea7c8bee3a08Test https://doi.org/10.1165/rcmb.2005-0100ocTest |
| رقم الانضمام: | edsair.doi.dedup.....f5c9a36f6b7b02a6756aea7c8bee3a08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354989 10441549 |
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