Surveillance of Antimalarial Resistance Molecular Markers in Imported Plasmodium falciparum Malaria Cases in Anhui, China, 2012–2016
| العنوان: | Surveillance of Antimalarial Resistance Molecular Markers in Imported Plasmodium falciparum Malaria Cases in Anhui, China, 2012–2016 |
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| المؤلفون: | Chen Yu, Tao Zhang, Xian Xu, Cuicui Tian, Weidong Li, Jingjing Jiang |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 98:1132-1136 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_treatment, Plasmodium falciparum, 030106 microbiology, 030231 tropical medicine, Drug Resistance, Protozoan Proteins, Dihydroartemisinin, Amodiaquine, Gene mutation, Antimalarials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Virology, Piperaquine, parasitic diseases, medicine, Humans, Point Mutation, ATP Binding Cassette Transporter, Subfamily B, Member 1, Malaria, Falciparum, Artemisinin, biology, Membrane Transport Proteins, Articles, Middle Aged, biology.organism_classification, medicine.disease, Infectious Diseases, chemistry, Artesunate, Female, Parasitology, Biomarkers, Malaria, medicine.drug |
| الوصف: | Between 2012 and 2016, over 80% of registered malaria cases in Anhui province were Plasmodium falciparum returned from Africa. However, drug-resistance marker polymorphisms in imported P. falciparum cases have not been assessed. This study looked at the distribution of antimalarial–drug resistance by evaluating K13-propeller, pfmdr1, and pfcrt gene mutations. Fourteen synonymous and 15 nonsynonymous mutations in the K13-propeller gene were detected in samples from nine African countries, yet no candidate and validated K13 resistance mutations were found. The prevalence of pfcrt K76T and pfmdr1 N86Y mutants was 27.7% and 19.9%, respectively. Six different pfcrt genotypes were found, with C(72)V(73)M(74)N(75)T(76) being the most common (89.2%). The pfcrt 76-pfmdr1 86 haplotype combination was evaluated in 173 isolates, and the N(86)T(76) genotype was the most prevalent (50.3%). Notably, the prevalence of the N86Y mutation in Africa marked a decline from 31.0% in 2012 to 8.2% in 2016. Our findings suggest that there is no immediate threat to artemisinin efficacy in imported P. falciparum infections returned from Africa to Anhui province. Nevertheless, pfcrt K76T and pfmdr1 N86Y mutations were modestly prevalent, suggesting the presence of chloroquine resistance in these cases. Accordingly, dihydroartemisinin + piperaquine may be a better choice than artesunate + amodiaquine for the treatment of uncomplicated P. falciparum infections in Anhui province. In addition to, artemether–lumefantrine can be introduced as an alternative measure. |
| تدمد: | 1476-1645 0002-9637 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc52b902a0d6e38c1c381265775b7579Test https://doi.org/10.4269/ajtmh.17-0864Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dc52b902a0d6e38c1c381265775b7579 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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