Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a
| العنوان: | Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a |
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| المؤلفون: | Tatsuro Irimura, Nobuaki Higashi, Thandi M. Onami, Yosuke Kumamoto, Yasuyuki Imai, Kayoko Sato, Stephen M. Hedrick |
| المصدر: | Blood. 106:207-215 |
| بيانات النشر: | American Society of Hematology, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Myeloid, T-Lymphocytes, Immunology, Asialoglycoproteins, Endogeny, Biochemistry, Mice, Antigen, medicine, Animals, Macrophage, Lectins, C-Type, Scleroderma, Systemic, biology, Air, Macrophages, Antibodies, Monoclonal, Membrane Proteins, Lectin, Interleukin, Granulation tissue, Cell Biology, Hematology, Mice, Mutant Strains, Recombinant Proteins, Body Fluids, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, Granulation Tissue, biology.protein, Antibody, Interleukin-1 |
| الوصف: | Macrophage galactose-type C-type lectins (MGLs), which were recently named CD301, have 2 homologues in mice: MGL1 and MGL2. MGLs are expressed on macrophages and immature dendritic cells. The persistent presence of granulation tissue induced by a protein antigen was observed in wild-type mice but not in mice lacking an endogenous, macrophage-specific, galactose-type calcium-type lectin 1 (MGL1) in an air pouch model. The anti-MGL1 antibody suppressed the granulation tissue formation in wild-type mice. A large number of cells, present only in the pouch of MGL1-deficient mice, were not myeloid or lymphoid lineage cells and the number significantly declined after administration of interleukin 1 α (IL-1α) into the pouch of MGL1-deficient mice. Furthermore, granulation tissue was restored by this treatment and the cells obtained from the pouch of MGL1-deficient mice were incorporated into the granulation tissue when injected with IL-1α. Taken together, MGL1 expressed on a specific subpopulation of macrophages that secrete IL-1α was proposed to regulate specific cellular interactions crucial to granulation tissue formation. |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110b5e8f11b209d2c63a3b155c10f6eaTest https://doi.org/10.1182/blood-2004-12-4943Test |
| رقم الانضمام: | edsair.doi.dedup.....110b5e8f11b209d2c63a3b155c10f6ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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