Deletion of Pten in CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies
| العنوان: | Deletion of Pten in CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies |
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| المؤلفون: | Xavier Dolcet, Cristina Mirantes, Sonia Gatius, Jian Yang, Felip Vilardell, Maria Alba Dosil, David Hills, Maria Santacana, Nuria Eritja, Xavier Matias-Guiu, Alexander Medvinsky |
| المصدر: | Medvinsky, A, Hills, D, Mirantes, C & Dosil, M A 2016, ' Deletion of Pten of CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies ', Blood, vol. 127, no. 5, pp. 1907-1911 . https://doi.org/10.1182/blood-2015-09-669036Test |
| بيانات النشر: | American Society of Hematology, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Myeloid, T cell, Immunology, Bone Marrow Cells, Kaplan-Meier Estimate, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Conditional gene knockout, medicine, Animals, PTEN, Mice, Knockout, Lymphoid Neoplasia, Myeloproliferative Disorders, Recombinase activity, Integrases, biology, Lymphoblastic lymphoma, PTEN Phosphohydrolase, Cell Biology, Hematology, Flow Cytometry, Hematopoietic Stem Cells, medicine.disease, Disease Models, Animal, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Leukocyte Common Antigens, Female, Stem cell, Gene Deletion |
| الوصف: | Since its discovery in the late 1990s, Pten has turned out to be one of the most important tumor suppressor genes. Pten loss results in increased activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, which is associated with increased proliferation, survival, and neoplastic growth. Here, we have addressed the effects of conditional deletion of Pten in hematopoietic cells by crossing Pten conditional knockout mice with a knock-in mouse expressing the Cre recombinase in the CD45 locus. CD45 is also known as leukocyte common antigen, and it is expressed in virtually all white cells and in hematopoietic stem cells. Using a reporter mouse, we demonstrate that CD45:Cre mouse displays recombinase activity in both myeloid and lymphoid cells. However, deletion of Pten in CD45-expressing cells induces development of T-cell acute lymphoblastic leukemia and lymphoma, but not other hematologic malignancies. |
| وصف الملف: | application/pdf |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3439188e8584edc4de99bac12bfdebafTest https://doi.org/10.1182/blood-2015-09-669036Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3439188e8584edc4de99bac12bfdebaf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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