Links Between DNA Damage and Metabolism, Pathways Causing Bone Marrow Failure in Fanconi Anemia, and Therapeutic Implications
| العنوان: | Links Between DNA Damage and Metabolism, Pathways Causing Bone Marrow Failure in Fanconi Anemia, and Therapeutic Implications |
|---|---|
| المؤلفون: | Ketan J. Patel |
| المصدر: | Blood. 120:SCI-3 |
| بيانات النشر: | American Society of Hematology, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | education.field_of_study, DNA damage, Immunology, Population, Bone marrow failure, Cell Biology, Hematology, DNA Repair Pathway, Biology, medicine.disease, Biochemistry, Leukemia, chemistry.chemical_compound, chemistry, Fanconi anemia, medicine, Stem cell, education, DNA |
| الوصف: | Abstract SCI-3 Recent work from my lab has discovered that metabolism generates reactive aldehydes. These reactive molecules are potent damagers of DNA. The consequences of this are revealed by the inactivation of enzymes that detoxify these aldehydes and the Fanconi anemia DNA repair pathway in mice and vertebrate cell lines. The scientific session presentation will discuss this work and recent unpublished research on how natural aldehydes damage blood stem cells. This work has consequences for understanding how metabolism and ethanol exposure can be genotoxic, particularly in the vast population of Southeast Asians carrying a genetic defect in aldehyde catabolism (“pink flushers”). It is also relevant to the emergence of bone marrow failure and leukemia in Fanconi anemia. Disclosures: No relevant conflicts of interest to declare. |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::0754cf84693629f48673860a9f946ee5Test https://doi.org/10.1182/blood.v120.21.sci-3.sci-3Test |
| رقم الانضمام: | edsair.doi...........0754cf84693629f48673860a9f946ee5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
|---|