Increased Oxygen Supply in Metabolic Syndrome Patients Treated with Gingko Biloba
| العنوان: | Increased Oxygen Supply in Metabolic Syndrome Patients Treated with Gingko Biloba |
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| المؤلفون: | G. Siegel, Eugeny A. Ermilov, Felicitas Mockenhaupt |
| المصدر: | Blood. 124:4876-4876 |
| بيانات النشر: | American Society of Hematology, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, medicine.diagnostic_test, business.industry, Ginkgo biloba, Immunology, C-reactive protein, Cell Biology, Hematology, Hematocrit, medicine.disease, biology.organism_classification, medicine.disease_cause, Biochemistry, Insulin resistance, Endocrinology, Internal medicine, medicine, biology.protein, Hemoglobin, Metabolic syndrome, business, Perfusion, Oxidative stress |
| الوصف: | Background: In Swiss mountaineers, it was observed that they did not suffer from O2 deficiency even in high altitude with diminished O2 partial pressures, if they had taken gingko. In a pilot study with 11 metabolic syndrome patients, who received as therapy 2 × 120 mg/d Gingko biloba special extract EGb 761 (Rökan novoÒ: Spitzner Arzneimittel, Ettlingen; TeboninÒ: Schwabe Pharmaceutical, Karlsruhe, Germany) over 2 months, it should be proven whether a change of the blood parameters MCH, MCHC, MCV and Hct could eventually supply a mechanistic explanation. Methods: Photometric methods, commercial ELISAs and EIAs, and clinical routine chemistry were applied. Results: MCH was increased from 27.7 ± 0.9 to 28.6 ± 1.0 pg (p < 0.0003), a change of +3.2% (p < 0.0044), MCHC from 317.7 ± 2.5 to 333.0 ± 3.1 g/L (p < 0.0), a change of +4.8% (p < 0.001), while Hct was decreased from 0.463 ± 0.011 to 0.407 ± 0.009 vol/vol (p < 0.0), a change of -12.0% (p < 0.001). Additionally, alterations in several biomarkers were measured: SOD +17.7% (p < 0.009), oxLDL/LDL -21.0% (p < 0.002), MPO -29.6% (p < 0.013), hs-CRP -39.3% (p < 0.004), HOMA-IR -14.0% (p < 0.024), CREA -11.3% (p < 0.001), ALT -16.0% (p < 0.0208). The table demonstrates the results of a linear correlation analysis between these biomarker changes and the changes in Hct and MCHC showing calculated Pearson’s correlation coefficients r and error probabilities p. Discussion: Even though the additional load of the single erythrocyte with an increased hemoglobin concentration seems insignificant, it is, however, decisive for the O2-saturation of the blood. Decrease of the hematocrit from 46.3% to 40.7% signalizes a normalization of the initially elevated value in these metabolic syndrome patients. Possibly, this lowering by 12.0% would not have been so distinct in a normal person. Reduction of oxidative stress, inflammatory parameters as well as decrease in insulin resistance offer an explanation for the increase in MCH and MCHC. Conclusion: With the intake of ginkgo, a better O2-supply for organs and tissues is guaranteed not only through an increased blood perfusion but also through an improved load of the single erythrocyte with hemoglobin (MCHC) by 4.8% as well as through reduction of the hematocrit (Hct) by 12.0%. Figure 1 Figure 1. Disclosures Siegel: Schwabe Pharmaceutics, Karlsruhe, Germany: Research Funding. |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::3c226586550c1605d7d3e077a724679bTest https://doi.org/10.1182/blood.v124.21.4876.4876Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........3c226586550c1605d7d3e077a724679b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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