Chronic Kidney Disease and Mild Elevations in Pulmonary Arterial Systolic Pressure Are Associated with Increased Mortality in Adult Patients with Sickle Cell Disease
| العنوان: | Chronic Kidney Disease and Mild Elevations in Pulmonary Arterial Systolic Pressure Are Associated with Increased Mortality in Adult Patients with Sickle Cell Disease |
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| المؤلفون: | Daniel Spevack, Jane A. Little, Daniel Lorch |
| المصدر: | Blood. 114:1539-1539 |
| بيانات النشر: | American Society of Hematology, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Creatinine, business.industry, Proportional hazards model, Immunology, Hazard ratio, Renal function, Cell Biology, Hematology, medicine.disease, Biochemistry, Sickle cell anemia, Surgery, chemistry.chemical_compound, Blood pressure, chemistry, Interquartile range, Internal medicine, medicine, Cardiology, business, Kidney disease |
| الوصف: | Abstract 1539 Poster Board I-562 Background Pulmonary arterial hypertension (PAH) has recently been shown to be an important predictor of prognosis in sickle cell disease (SCD). We studied this association in a large population of adults with SCD. Methods and Results 215 patients with sickle cell syndromes in whom echoes had been performed, 113 as outpatients and 102 as inpatients, were identified from our database. Clinical characteristics were analyzed, and survival data were extracted from a national mortality registry. At the time of examination, subjects were 39 ± 14 years old, with hematocrits (Hcts) of 23.6 ± 4.4. 78 out of 213 patients who had undergone echoes had PAH (PASP ≥ 40 mmHg) on echocardiogram. Those patients were older (41 ± 15 vs 37 ± 13 years, p=0.03), had higher creatinine values (1.3 vs 0.9 mg/dL, p=0.01) higher serum alkaline phosphatase levels (172.2 ± 23.2 vs 104.5 ± 5.5 U/L, p=.0058), and were more often taking anti-hypertensive medications (38 vs 17%, p Conclusion In a community-based academic center, we found that mild elevation in PASP on echocardiogram, whenever obtained (see figure), depressions in eGFR (see figure), and hyperbilirubinemia were highly predictive for mortality in sickle cell disease. It is unclear whether these relationships are causal or an epiphenomenon of severe underlying disease. Hemolysis (lower Hcts, higher Lactate dehydrogenase levels), implicated in other studies, was not prominent in the PAH cohort. Disclosures No relevant conflicts of interest to declare. |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a15647039cdf0188a327009cd97d76eaTest https://doi.org/10.1182/blood.v114.22.1539.1539Test |
| رقم الانضمام: | edsair.doi...........a15647039cdf0188a327009cd97d76ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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