دورية أكاديمية
EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15
| العنوان: | EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15 |
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| المؤلفون: | Giron-Michel, J., Menard, F., Negrini, S., Devocelle, A., Azzarone, B., Besson, C. |
| المساهمون: | Giron-Michel, J., Menard, F., Negrini, S., Devocelle, A., Azzarone, B., Besson, C. |
| بيانات النشر: | American Society of Hematology |
| سنة النشر: | 2009 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | Apoptosis, Western blotting, Case-Control Studies, CD8-Positive T-Lymphocytes, Epstein-Barr Virus Infections, Flow Cytometry, Herpesvirus 4, Humans, Infectious Mononucleosis, Interleukin-15, Interleukin-15 Receptor alpha Subunit, Phosphorylation, STAT5 Transcription Factor |
| الوصف: | It has been reported that infectious mononucleosis (IM)-symptomatic primary Epstein-Barr virus infection produces a global down-regulation of interleukin-15 receptor-α (IL-15Rα) on T cells and natural killer cells associated with a defective IL-15 responsiveness that lasts for many years after the disease episode. In contrast with these results, our data indicate that, in the T-cell compartment derived from remote IM subjects, there is no quantitative or qualitative defect in the expression of the IL-15Rα chain and no deficit in T-cell responsiveness to IL-15. We observed efficient signal transduction, survival, and proliferation even in response to low IL-15 concentrations. These data are relevant and shed new light on the immune long-term response in IM subjects because they contradict the hypothesis that defects in Epstein-Barr virus-host immune balance may be correlated with a long-lasting global deficit in T-cell responsiveness to IL-15. © 2009 by The American Society of Hematology. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/19264676; info:eu-repo/semantics/altIdentifier/wos/WOS:000265910300016; volume:113 (19); firstpage:4541; lastpage:4547; numberofpages:7; journal:BLOOD; http://hdl.handle.net/11567/889517Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-66549121298 |
| DOI: | 10.1182/blood-2008-12-195289 |
| الإتاحة: | https://doi.org/10.1182/blood-2008-12-195289Test http://hdl.handle.net/11567/889517Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5864938A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood-2008-12-195289 |
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