التفاصيل البيبلوغرافية
| العنوان: |
Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells. |
| المؤلفون: |
Oduro Jr, Kwadwo A.1,2, Liu, Fang1, Tan, Qing1, Kim, Chan-Kyu1, Lubman, Olga1, Fremont, Daved1, Mills, Jason C.3,4, Choi, Kyunghee1,3 |
| المصدر: |
Blood. 9/13/2012, Vol. 120 Issue 11, p2203-2213. 11p. |
| مصطلحات موضوعية: |
*AUTOIMMUNE diseases, *ARTHRITIS, *HEMATOPOIETIC stem cells, *PROGENITOR cells, *INFLAMMATION, *LABORATORY mice |
| مستخلص: |
Skewing toward myeloid cell production is often observed in chronic inflammation and autoimmune diseases. Herein, we determined whether persistent myeloid activation and proinflammatory output oc-curring in pathologic conditions is at the level of hematopoietic stem and primitive progenitor cells (HSPPCs). By using a mouse arthritis model, we found that even though HSPPCs in arthritis still retained the capacity to differentiate into different lineages, they acquired enhanced in vitro and in vivo propensity in a disease-dependent manner to generate myeloid cells, the key perpetrators of tissue dam-age in arthritis. This myeloid skewing was cell intrinsic, as arthritic HSPPCs up-regulate myeloid-speclfic transcripts including S100a8. Exogenous S100a8 pro-moted myeloid cell output from wild-type HSPPCs, suggesting mechanistic involve-ment of this gene in the myeloid priming that occurs in arthritic HSPPCs. There-fore, our results Indicate that in arthritic mice, HSPPCs adopt a pathologic state that favors disease persistence. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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