Role of inflammatory monocyte mobilization in growth of liver metastasis in a murine model of metastatic pancreatic cancer
| العنوان: | Role of inflammatory monocyte mobilization in growth of liver metastasis in a murine model of metastatic pancreatic cancer |
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| المؤلفون: | David C. Linehan, Dominic E. Sanford, Roheena Z. Panni, Brian A. Belt, Timothy M. Nywening, Peter S. Goedegebuure |
| المصدر: | Journal of Clinical Oncology. 33:299-299 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, Mobilization, business.industry, Mortality rate, Inflammatory monocyte, medicine.disease, Metastasis, Oncology, Murine model, Pancreatic cancer, Metastatic pancreatic cancer, medicine, Cancer research, business, Cause of death |
| الوصف: | 299 Background: Pancreatic cancer (PC) is currently the fourth leading cause of death and the mortality rate approaches 100% due to early metastatic spread. Liver is the most common site of metastasis in PC. Our group and others have shown that PC induces cellular changes in the liver which include increase in inflammatory monocyte and macrophage population, long before development of metastasis. Based on our preliminary data, we developed a murine model of metastatic PC to study the role of chemotherapy in addition to novel IM blocking agents in established PC metastasis. Methods: We implanted spontaneously derived murine PC cell line (KCKO) orthotopically in the tail of pancreas of WT mice. 10 days after tumor implantation, there was an increase in infiltrating IM and macrophages in the liver by flow-cytometry and IHC. There was also an upregulation of genes associated with development of metastasis and recruitment of myeloid cells i.e. CCL2, CSF1, s100a4, s100a8, CXCL12, LOX, VEGF-A (P |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::aca9484528ddcb94ae6876d502454495Test https://doi.org/10.1200/jco.2015.33.3_suppl.299Test |
| رقم الانضمام: | edsair.doi...........aca9484528ddcb94ae6876d502454495 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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