Correlation of IDH mutation, 1p/19q co-deletion and 18FET-PET derived time-to-peak analysis as prognostic markers in glioma
| العنوان: | Correlation of IDH mutation, 1p/19q co-deletion and 18FET-PET derived time-to-peak analysis as prognostic markers in glioma |
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| المؤلفون: | Ulrich Schueller, Armin Giese, Bogdana Suchorska, Marcus Unterrainer, Theo F. J. Kraus, Christine Schmid-Tannwald, Michael Weller, Joerg C. Tonn, Peter Bartenstein, Annamaria Biczok, Nathalie L. Albert |
| المصدر: | Journal of Clinical Oncology. 34:2058-2058 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Pathology, Karnofsky Performance Status, business.industry, Who grade, medicine.disease, 030218 nuclear medicine & medical imaging, Idh mutation, Correlation, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Glioma, medicine, Overall survival, Time to peak, business |
| الوصف: | 2058Background: Stratification of glial tumors according to IDH mutation and 1p/19q co-deletion status will gain further importance for tumor classification and treatment in the near future. In analogy, factors derived from 18FET-PET uptake dynamics such as time-to-peak (TTP) analysis allow discrimination between different prognostic groups. The present study aims at correlating molecular tumor characteristics and TTP analysis and to analyze associations with clinical outcome. Methods: 300 patients with de novo WHO grade II-IV gliomas with 18FET-PET imaging at diagnosis were grouped according to IDH mutation and 1p/19q co-deletion status into 3 subgroups (IDH wildtype, IDH mut/non co-del 1p/19q and IDH mut/co-del 1p/19q). Clinical and imaging factors such as age, Karnofsky performance status, treatment and 18FET-PET derived TTP analysis were analyzed with regard to progression-free and overall survival (PFS and OS) via univariate and multivariate regression analysis. Results: PFS and OS was longest in the... |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::710735db11b69f63a98eaff123ce8e69Test https://doi.org/10.1200/jco.2016.34.15_suppl.2058Test |
| رقم الانضمام: | edsair.doi...........710735db11b69f63a98eaff123ce8e69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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