Safety and efficacy of pegfilgrastim in pediatric oncology patients: The M.D. Anderson Cancer Center experience
| العنوان: | Safety and efficacy of pegfilgrastim in pediatric oncology patients: The M.D. Anderson Cancer Center experience |
|---|---|
| المؤلفون: | I. Ramirez, S. E. Koontz, Norman Jaffe, R. B. Raney, M. Pearson, L. R. Mohassel, Christian Herzog |
| المصدر: | Journal of Clinical Oncology. 22:8272-8272 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Cancer Research, Pediatrics, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Cancer, Filgrastim, Neutropenia, medicine.disease, Surgery, Chemotherapy cycle, Oncology, medicine, Pediatric oncology, business, Pegfilgrastim, medicine.drug |
| الوصف: | 8272 Background: The growth factor filgrastim (G-CSF) reduces the severity and duration of neutropenia in cancer patients. Due to its short half-life, it has to be injected daily, usually for 7–10 days, which is a special challenge in treating children. Pegfilgrastim, a pegylated form of G-CSF, has a long half-life and thus only has to be injected once per chemotherapy cycle. Data on the use of pegfilgrastim in children is limited. Therefore we evaluated the safety and efficacy of pegfilgrastim in children. Methods: To date, we have retrospectively reviewed the charts of 21 pediatric patients (12 males, ages 4–20, median 13 yrs) with various cancers (19 solid tumors and 2 lymphomas) who received pegfilgrastim. All patients had life expectancy > 6 weeks and baseline lab values acceptable to receive chemotherapy. A total of 101 doses (median/patient 5, range 2–9) of pegfilgrastim were administered (98% 24–72 hours post-chemotherapy). Patients ≥ 45 kg received 6 mg each (44 doses), and patients < 45 kg recei... |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::cf905e1c861ded195eedd38e78c8fc17Test https://doi.org/10.1200/jco.2004.22.90140.8272Test |
| رقم الانضمام: | edsair.doi...........cf905e1c861ded195eedd38e78c8fc17 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
|---|