المؤلفون: Pfeiler, Georg, Hlauschek, Dominik, Mayer, Erica L., Deutschmann, Christine, Kacerovsky-Strobl, Stephanie, Martin, Miguel, Meisel, Jane Lowe, Zdenkowski, Nicholas, Loibl, Sibylle, Balic, Marija, Park, Haeseong, Prat, Aleix, Isaacs, Claudine, Bajetta, Emilio, Balko, Justin M., Bellet-Ezquerra, Merixtell, Bliss, Judith, Burstein, Harold, Cardoso, Fatima, Fohler, Hannes

المصدر: Journal of Clinical Oncology; 11/20/2023, Vol. 41 Issue 2, p5118-5130, 18p

المؤلفون: Li, Xuanyi, Park, Ben Ho, Balko, Justin M., Johnson, Douglas Buckner

المصدر: Journal of Clinical Oncology; 2023 Supplement 16, Vol. 41, p3138-3138, 1p

المؤلفون: Castellanos, Emily H., Feld, Emily, Estrada, Monica V., Sanders, Melinda E., Massion, Pierre P., Johnson, Douglas B., Balko, Justin M., Horn, Leora

المصدر: JCO Precision Oncology; 2017, Vol. 1 Issue 1, p1-9, 9p

مصطلحات موضوعية: NON-small-cell lung carcinoma, AXILLARY lymph node dissection

مستخلص: After his initial disease progression while receiving anti-PD-L1 therapy, repeat biopsy demonstrated no tumor PD-L1 staining (with limited stromal PD-L1 positivity), and PD-L2 remained strongly positive (70%; Fig 1C). This finding suggests that the significance of PD-L2 positivity in response to PD-L1 or PD-1 targeted therapies may be a useful subject of study. Although anecdotal, this case report demonstrates an important clinical finding: patients who become resistant to anti-PD-L1 may still benefit from PD-1 targeted therapies, possibly due to a switch from dependency on PD-L1 to PD-L2 for maintenance of immunosuppression. However, the presence of consistently high PD-L2 staining argues against a direct mechanism of PD-L2-mediated de novo resistance to anti-PD-L1 therapy. [Extracted from the article]

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المؤلفون: DeMichele, Angela, Dueck, Amylou C., Hlauschek, Dominik, Martin, Miguel, Burstein, Harold J., Pfeiler, Georg, Zdenkowski, Nicholas, Wolff, Antonio C., Balic, Marija, Miller, Kathy, Cameron, David A., Balko, Justin M., Traina, Tiffany A., Czajkowska, Dorota, Metzger, Otto, Lu, Dongrui Ray, O'Brien, Patrick, Fesl, Christian, Mayer, Erica L., Gnant, Michael

المصدر: Journal of Clinical Oncology; 10/20/2022 Supplement 36, Vol. 40, p390216-390216, 1p

المؤلفون: Mayer, Ingrid A, Abramson, Vandana G, Isakoff, Steven J, Forero, Andres, Balko, Justin M, Kuba, María Gabriela, Sanders, Melinda E, Yap, Jeffrey T, Van den Abbeele, Annick D, Li, Yisheng, Cantley, Lewis C, Winer, Eric, Arteaga, Carlos L

المصدر: Journal of Clinical Oncology; 4/20/2014, Vol. 32 Issue 12, p1202-1209, 8p

المؤلفون: Mayer, Ingrid A., Abramson, Vandana G., Isakoff, Steven J., Forero, Andres, Balko, Justin M., Kuba, María Gabriela, Sanders, Melinda E., Yap, Jeffrey T., Van den Abbeele, Annick D., Yisheng Li, Cantley, Lewis C., Winer, Eric, Arteaga, Carlos L.

المصدر: Journal of Clinical Oncology; 4/20/2014, Vol. 32 Issue 12, p1202-1209, 9p

المؤلفون: Miller, Todd W., Balko, Justin M., Arteaga, Carlos L.

المصدر: Journal of Clinical Oncology; 11/20/2011, Vol. 29 Issue 33, p4452-4461, 10p