دورية أكاديمية
Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores.
| العنوان: | Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores. |
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| المؤلفون: | Lecarpentier, Julie, Silvestri, Valentina, Kuchenbaecker, Karoline B, Barrowdale, Daniel, Dennis, Joe, McGuffog, Lesley, Soucy, Penny, Leslie, Goska, Rizzolo, Piera, Navazio, Anna Sara, Valentini, Virginia, Gutiérrez-Enríquez, Sara, Diez, Orland, Teulé, Alex, Izquierdo, Angel, Darder, Esther, Brunet, Joan, Del Valle, Jesús, Feliubadalo, Lidia, Pujana, Miquel Angel, Lazaro, Conxi, Zelli, Veronica, Arason, Adalgeir, Agnarsson, Bjarni A, Johannsson, Oskar Th, Barkardottir, Rosa B, Alducci, Elisa, Tognazzo, Silvia, Montagna, Marco, Teixeira, Manuel R, Pinto, Pedro, Spurdle, Amanda B, Lee, Andrew, Holland, Helene, Lee, Jong Won, Lee, Min Hyuk, Lee, Jihyoun, Kim, Sung-Won, Kang, Eunyoung, Kim, Zisun, Sharma, Priyanka, Rebbeck, Timothy R, Vijai, Joseph, Amin Al Olama, Ali, Robson, Mark, Lincoln, Anne, Musinsky, Jacob, Gaddam, Pragna, Tan, Yen Y, Berger, Andreas, Singer, Christian F, Loud, Jennifer T, Greene, Mark H, Mulligan, Anna Marie, Tyrer, Jonathan P, Glendon, Gord, Andrulis, Irene L, Toland, Amanda Ewart, Senter, Leigha, Bojesen, Anders, Nielsen, Henriette Roed, Skytte, Anne-Bine, Sunde, Lone, Jensen, Uffe Birk, Pedersen, Inge Sokilde, Southey, Melissa, Krogh, Lotte, Kruse, Torben A, Caligo, Maria A, Yoon, Sook-Yee, Teo, Soo-Hwang, von Wachenfeldt, Anna, Huo, Dezheng, Nielsen, Sarah M, Olopade, Olufunmilayo I, Nathanson, Katherine L, John, Esther M, Domchek, Susan M, Lorenchick, Christa, Jankowitz, Rachel C, Campbell, Ian, James, Paul, Mitchell, Gillian, Orr, Nick, Park, Sue Kyung, Thomassen, Mads, Offit, Kenneth, Conner, Thomas A, Couch, Fergus J, Simard, Jacques, Easton, Douglas F, Chenevix-Trench, Georgia, Schmutzler, Rita K, Antoniou, Antonis C, Ottini, Laura, Goldgar, David E, Buys, Saundra S, Janavicius, Ramunas, Steele, Linda, Ding, Yuan Chun, Neuhausen, Susan L, Hansen, Thomas V O, Osorio, Ana, Weitzel, Jeffrey N, Toss, Angela, Medici, Veronica, Cortesi, Laura, Zanna, Ines, Palli, Domenico, Radice, Paolo, Manoukian, Siranoush, Peissel, Bernard, Azzollini, Jacopo, Viel, Alessandra, Cini, Giulia, Damante, Giuseppe, Tommasi, Stefania, Peterlongo, Paolo, Fostira, Florentia, Hamann, Ute, Evans, D Gareth, Henderson, Alex, Brewer, Carole, Eccles, Diana, Cook, Jackie, Ong, Kai-Ren, Walker, Lisa, Side, Lucy E, Porteous, Mary E, Davidson, Rosemarie, Hodgson, Shirley, Frost, Debra, Adlard, Julian, Izatt, Louise, Eeles, Ros, Ellis, Steve, Tischkowitz, Marc, Godwin, Andrew K, Meindl, Alfons, Gehrig, Andrea, Dworniczak, Bernd, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Doris, Hahnen, Eric, Hauke, Jan, Rhiem, Kerstin, Kast, Karin, Arnold, Norbert, Ditsch, Nina, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Wand, Dorothea, Lasset, Christine, Stoppa-Lyonnet, Dominique, Belotti, Muriel, Damiola, Francesca, Barjhoux, Laure, Mazoyer, Sylvie, Van Heetvelde, Mattias, Poppe, Bruce, De Leeneer, Kim, Claes, Kathleen B M, de la Hoya, Miguel, Garcia-Barberan, Vanesa, Caldes, Trinidad, Perez Segura, Pedro, Kiiski, Johanna I, Aittomäki, Kristiina, Khan, Sofia, Nevanlinna, Heli, van Asperen, Christi J, Vaszko, Tibor, Kasler, Miklos, Olah, Edith, Balmaña, Judith |
| المساهمون: | 1 Univ Cambridge, Cambridge, England Show the Organization-Enhanced name(s) 2 Wellcome Trust Sanger Inst, Hinxton, England Show the Organization-Enhanced name(s) 3 Addenbrookes Hosp, Addenbrookes Treatment Ctr, Cambridge, England Show the Organization-Enhanced name(s) 4 Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England 5 Newcastle Tyne Hosp NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England Show the Organization-Enhanced name(s) 6 Royal Devon & Exeter Hosp, Exeter, Devon, England Show the Organization-Enhanced name(s) 7 Southampton Univ Hosp NHS Trust, Southampton, Hants, England 8 Sheffield Childrens Hosp, Sheffield, S Yorkshire, England 9 Birmingham Womens Hosp Healthcare NHS Trust, Birmingham, W Midlands, England Show the Organization-Enhanced name(s) 10 Churchill Hosp, Oxford, England Show the Organization-Enhanced name(s) 11 Great Ormond St Hosp Sick Children, London, England Show the Organization-Enhanced name(s) 12 St Georges Univ London, London, England Show the Organization-Enhanced name(s) 13 Guys & St Thomas NHS Fdn Trust, London, England Show the Organization-Enhanced name(s) 14 Inst Canc Res, London, England Show the Organization-Enhanced name(s) 15 Royal Marsden NHS Fdn Trust, London, England Show the Organization-Enhanced name(s) 16 Western Gen Hosp, Edinburgh, Midlothian, Scotland 17 South Glasgow Univ Hosp, Glasgow, Lanark, Scotland 18 Chapel Allerton Hosp, Leeds, W Yorkshire, England Show the Organization-Enhanced name(s) 19 Sapienza Univ Rome, Rome, Italy Show the Organization-Enhanced name(s) 20 Univ Modena & Reggio Emilia, Modena, Italy 21 Canc Res & Prevent Inst, Florence, Italy 22 Fdn Ist Ricovero & Cura Carattere Sci, INT, Milan, Italy 23 Italian Fdn Canc Res, Inst Mol Oncol IFOM, Milan, Italy Show the Organization-Enhanced name(s) 24 Natl Canc Inst, CRO Aviano, Aviano, Italy Show the Organization-Enhanced name(s) 25 Univ Udine, Udine, Italy 26 Ist Nazl Tumori Giovanni Paolo II, Bari, Italy Show the Organization-Enhanced name(s) 27 Veneto Inst Oncol IOV IRCCS, Padua, Italy Show the Organization-Enhanced name(s) 28 Univ Pisa, Pisa, Italy 29 Univ Hosp Pisa, Pisa, Italy 30 Ctr Hosp Univ Quebec Res Ctr, Quebec City, PQ, Canada Show the Organization-Enhanced name(s) 31 Laval Univ, Quebec City, PQ, Canada Show the Organization-Enhanced name(s) 32 Univ Toronto, Toronto, ON, Canada Show the Organization-Enhanced name(s) 33 Mt Sinai Hosp, Toronto, ON, Canada Show the Organization-Enhanced name(s) 34 Univ Melbourne, Parkville, Vic, Australia Show the Organization-Enhanced name(s) 35 QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia Show the Organization-Enhanced name(s) 36 Peter MacCallum Canc Ctr, East Melbourne, NSW, Australia Show the Organization-Enhanced name(s) 37 Canc Prevent Inst Calif, Fremont, CA USA Show the Organization-Enhanced name(s) 38 City Hope Natl Med Ctr, Duarte, CA USA 39 Huntsman Canc Inst, Salt Lake City, UT USA Show the Organization-Enhanced name(s) 40 Univ Utah, Sch Med, Salt Lake City, UT USA Show the Organization-Enhanced name(s) 41 Univ Kansas, Med Ctr, Kansas City, KS 66103 USA Show the Organization-Enhanced name(s) 42 Univ Kansas, Med Ctr, Westwood, KS USA 43 Harvard TH Chan Sch Publ Hlth, Boston, MA USA Show the Organization-Enhanced name(s) 44 Dana Farber Canc Inst, Boston, MA 02115 USA Show the Organization-Enhanced name(s) 45 Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA Show the Organization-Enhanced name(s) 46 NCI, Bethesda, MD 20892 USA Show the Organization-Enhanced name(s) 47 Ohio State Univ, Columbus, OH 43210 USA Show the Organization-Enhanced name(s) 48 Univ Chicago, Med Ctr, Chicago, IL 60637 USA Show the Organization-Enhanced name(s) 49 Univ Penn, Philadelphia, PA 19104 USA Show the Organization-Enhanced name(s) 50 Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA Show the Organization-Enhanced name(s) 51 Mayo Clin, Rochester, MN USA Show the Organization-Enhanced name(s) 52 State Res Inst Innovat Med Ctr, Vilnius, Lithuania Show the Organization-Enhanced name(s) 53 Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark 54 Vejle Hosp, Vejle, Denmark Show the Organization-Enhanced name(s) 55 Aarhus Univ Hosp, Aarhus, Denmark Show the Organization-Enhanced name(s) 56 Aalborg Univ Hosp, Aalborg, Denmark 57 Odense Univ Hosp, Odense, Denmark 58 Natl Canc Res Ctr, Madrid, Spain 59 Spanish Network Rare Dis, Madrid, Spain Show the Organization-Enhanced name(s) 60 Hosp Clin San Carlos, Inst Invest Sanitaria, Madrid, Spain Show the Organization-Enhanced name(s) 61 Univ Hosp, Barcelona, Spain Show the Organization-Enhanced name(s) 62 Vall dHebron Inst Oncol, Barcelona, Spain 63 Univ Hosp Vall dHebron, Barcelona, Spain Show the Organization-Enhanced name(s) 64 Catalan Inst Oncol, Bellvitge Biomed Res Inst, Barcelona, Spain Show the Organization-Enhanced name(s) 65 Catalan Inst Oncol, Inst Invest Biomed Girona, Girona, Spain 66 Natl Ctr Sci Res Demokritos, Athens, Greece Show the Organization-Enhanced name(s) 67 German Canc Res Ctr, Heidelberg, Germany Show the Organization-Enhanced name(s) 68 Univ Hosp Heidelberg, Heidelberg, Germany Show the Organization-Enhanced name(s) 69 Tech Univ Munich, Klinikumrechts Isar, Munich, Germany Show the Organization-Enhanced name(s) 70 Ludwig Maximilians Univ Munchen, Munich, Germany Show the Organization-Enhanced name(s) 71 Univ Wurzburg, Wurzburg, Germany Show the Organization-Enhanced name(s) 72 Univ Munster, Munster, Germany Show the Organization-Enhanced name(s) 73 Univ Leipzig, Leipzig, Germany Show the Organization-Enhanced name(s) 74 Univ Hosp, Leipzig, Germany Show the Organization-Enhanced name(s) 75 Heinrich Heine Univ, Univ Hosp Dusseldorf, Dusseldorf, Germany Show the Organization-Enhanced name(s) 76 Hannover Med Sch, Hannover, Germany Show the Organization-Enhanced name(s) 77 Univ Hosp Cologne, Cologne, Germany Show the Organization-Enhanced name(s) 78 Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany Show the Organization-Enhanced name(s) 79 Christian Albrechts Univ Kiel, Univ Hosp Schleswig Holstein, Kiel, Germany Show the Organization-Enhanced name(s) 80 Univ Hosp Ulm, Ulm, Germany Show the Organization-Enhanced name(s) 81 Ctr Leon Berard, Lyon, France Show the Organization-Enhanced name(s) 82 Univ Lyon, Lyon, France Show the Organization-Enhanced name(s) 83 Inst Curie, Paris, France Show the Organization-Enhanced name(s) 84 Univ Ghent, Ghent, Belgium Show the Organization-Enhanced name(s) 85 Univ Helsinki, Helsinki, Finland Show the Organization-Enhanced name(s) 86 Helsinki Univ Hosp, Helsinki, Finland Show the Organization-Enhanced name(s) 87 Leiden Univ, Med Ctr, Leiden, Netherlands Show the Organization-Enhanced name(s) 88 Natl Inst Oncol, Budapest, Hungary Show the Organization-Enhanced name(s) 89 Univ Iceland, Landspitali Univ Hosp, Reykjavik, Iceland Show the Organization-Enhanced name(s) 90 Univ Iceland, Biomed Ctr, Reykjavik, Iceland Show the Organization-Enhanced name(s) 91 Portuguese Oncol Inst, Oporto, Portugal Show the Organization-Enhanced name(s) 92 Univ Porto, Oporto, Portugal Show the Organization-Enhanced name(s) 93 Ulsan Coll Med, Seoul, South Korea 94 Asan Med Ctr, Seoul, South Korea 95 Soonchunhyang Univ & Hosp, Seoul, South Korea Show the Organization-Enhanced name(s) 96 Daerim St Marys Hosp, Seoul, South Korea Show the Organization-Enhanced name(s) 97 Seoul Natl Univ, Coll Med, Seoul, South Korea Show the Organization-Enhanced name(s) 98 Soonchunhyang Univ, Bucheon Hosp, Bucheon, South Korea Show the Organization-Enhanced name(s) 99 Med Univ Vienna, Vienna, Austria 100 Sime Darby Med Ctr, Subang Jaya, Malaysia Show the Organization-Enhanced name(s) 101 Karolinska Univ Hosp, Stockholm, Sweden |
| بيانات النشر: | American Society of Clinical Oncology |
| سنة النشر: | 2017 |
| المجموعة: | Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: | Brjóstakrabbamein, Blöðruhálskirtilskrabbamein, Gen, Karlar, MAO12, PTT12, NAF12, Genes, BRCA1, BRCA2, Mutation, Breast Neoplasms, Male, Prostatic Neoplasms |
| الوصف: | To access publisher's full text version of this article click on the hyperlink below ; Purpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We investigated-for the first time to our knowledge-associations of common genetic variants with breast and prostate cancer risks for male carriers of BRCA1/ 2 mutations and implications for cancer risk prediction. Materials and Methods We genotyped 1,802 male carriers of BRCA1/2 mutations from the Consortium of Investigators of Modifiers of BRCA1/2 by using the custom Illumina OncoArray. We investigated the combined effects of established breast and prostate cancer susceptibility variants on cancer risks for male carriers of BRCA1/2 mutations by constructing weighted polygenic risk scores (PRSs) using published effect estimates as weights. Results In male carriers of BRCA1/2 mutations, PRS that was based on 88 female breast cancer susceptibility variants was associated with breast cancer risk (odds ratio per standard deviation of PRS, 1.36; 95% CI, 1.19 to 1.56; P = 8.6 × 10(-6)). Similarly, PRS that was based on 103 prostate cancer susceptibility variants was associated with prostate cancer risk (odds ratio per SD of PRS, 1.56; 95% CI, 1.35 to 1.81; P = 3.2 × 10(-9)). Large differences in absolute cancer risks were observed at the extremes of the PRS distribution. For example, prostate cancer risk by age 80 years at the 5th and 95th percentiles of the PRS varies from 7% to 26% for carriers of BRCA1 mutations and from 19% to 61% for carriers of BRCA2 mutations, respectively. Conclusion PRSs may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management. ; Association for Cancer Research [AIRC] Ministere de l'E'conomie, Innovation et Exportation du Quebec Grant Government of Canada through ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1527-7755 |
| العلاقة: | Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores. 2017, 35 (20):2240-2250 J. Clin. Oncol.; http://hdl.handle.net/2336/620286Test; Journal of clinical oncology : official journal of the American Society of Clinical Oncology |
| DOI: | 10.1200/JCO.2016.69.4935 |
| الإتاحة: | https://doi.org/10.1200/JCO.2016.69.4935Test http://hdl.handle.net/2336/620286Test |
| حقوق: | Archived with thanks to Journal of clinical oncology : official journal of the American Society of Clinical Oncology ; Landspitali Access - LSH-aðgangur |
| رقم الانضمام: | edsbas.3D1420D |
| قاعدة البيانات: | BASE |
| تدمد: | 15277755 |
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| DOI: | 10.1200/JCO.2016.69.4935 |