Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk
| العنوان: | Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk |
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| المؤلفون: | Sven Sandin, Britton Trabert, Amy Berrington de Gonzalez, Martha S. Linet, Alpa V. Patel, Charles E. Matthews, Alicja Wolk, Neal D. Freedman, Susan M. Gapstur, Steven C. Moore, Wen-Yi Huang, Roger L. Milne, Michael B. Cook, Eric J. Shiroma, Niclas Håkansson, I-Min Lee, Cari M. Kitahara, Hannah Arem, Susanna C. Larsson, Brigid M. Lynch |
| المصدر: | Journal of Clinical Oncology J Clin Oncol |
| بيانات النشر: | American Society of Clinical Oncology, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Risk, Cancer Research, medicine.medical_specialty, Colorectal cancer, Leisure time, Physical activity, Motor Activity, Metabolic equivalent, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Leisure Activities, Internal medicine, Neoplasms, Metabolic Equivalent, Original Reports, Medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Exercise, Aged, Aged, 80 and over, 2. Zero hunger, Cancer och onkologi, business.industry, Prevention, Editorials, Middle Aged, medicine.disease, United States, 3. Good health, Intensity (physics), Oncology, Cancer and Oncology, 030220 oncology & carcinogenesis, Female, business, Cancer risk, Risk Reduction Behavior, Cohort study |
| الوصف: | PURPOSE To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk, describe the shape of the dose-response relationship, and explore associations with moderate- and vigorous-intensity physical activity. METHODS Data from 9 prospective cohorts with self-reported leisure-time physical activity and follow-up for cancer incidence were pooled. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% CIs of the relationships between physical activity with incidence of 15 types of cancer. Dose-response relationships were modeled with restricted cubic spline functions that compared 7.5, 15.0, 22.5, and 30.0 MET hours/week to no leisure-time physical activity, and statistically significant associations were determined using tests for trend ( P < .05) and 95% CIs (< 1.0). RESULTS A total of 755,459 participants (median age, 62 years [range, 32-91 years]; 53% female) were followed for 10.1 years, and 50,620 incident cancers accrued. Engagement in recommended amounts of activity (7.5-15 MET hours/week) was associated with a statistically significant lower risk of 7 of the 15 cancer types studied, including colon (8%-14% lower risk in men), breast (6%-10% lower risk), endometrial (10%-18% lower risk), kidney (11%-17% lower risk), myeloma (14%-19% lower risk), liver (18%-27% lower risk), and non-Hodgkin lymphoma (11%-18% lower risk in women). The dose response was linear in shape for half of the associations and nonlinear for the others. Results for moderate- and vigorous-intensity leisure-time physical activity were mixed. Adjustment for body mass index eliminated the association with endometrial cancer but had limited effect on other cancer types. CONCLUSION Health care providers, fitness professionals, and public health practitioners should encourage adults to adopt and maintain physical activity at recommended levels to lower risks of multiple cancers. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1527-7755 0732-183X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34cefd400dbe8ff72f6baaab43205a2Test http://europepmc.org/articles/PMC7048166Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b34cefd400dbe8ff72f6baaab43205a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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