دورية أكاديمية
Influence of pre- and post-transplantation responses on outcome of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival
| العنوان: | Influence of pre- and post-transplantation responses on outcome of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival |
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| المؤلفون: | Lahuerta, Juan José, Mateos Manteca, María Victoria, Martínez-López, Joaquin, Rosiñol, Laura, Sureda, Anna, De la Rubia, Javier, García-Laraña, José, Martínez-Martínez, Rafael, Hernández-García, Miguel T., Carrera, Dolores, Besalduch, Joan, De Arriba, Felipe, Ribera, José-María, Escoda, Lourdes, Hernández-Ruiz, Belén, García-Frade, Javier, Rivas-González, Concepción, Alegre, Adrian, Bladé, Joan, San Miguel Izquierdo, Jesús Fernando |
| بيانات النشر: | American Society of Clinical Oncology |
| سنة النشر: | 2008 |
| المجموعة: | Universidad de Salamanca: Gredos (Gestión del Repositorio Documental de la Universidad de Salamanca) |
| مصطلحات موضوعية: | Mieloma múltiple, Disease-Free Survival, Transplantation, Aged, Kaplan-Meier Estimate, Transplantation Conditioning, Adult, Humans, Antineoplastic Combined Chemotherapy Protocols, Middle Aged, Multiple Myeloma, Prospective Studies, Time Factors, Stem Cell Transplantation, Treatment Outcome, Remission Induction, protocolos de quimioterapia antineoplásica combinada, trasplante de células madre, humanos, inducción de remisión, factores de tiempo, anciano, trasplante, mediana edad, supervivencia sin enfermedad, estudios prospectivos, adulto, acondicionamiento para el trasplante, resultado del tratamiento, estimación de Kaplan-Meier |
| الوصف: | [EN]Complete response (CR) is considered an important goal in most hematologic malignancies. However, in multiple myeloma (MM), there is no consensus regarding whether immunofixation (IF)-negative CR, IF-positive near-CR (nCR), and partial response (PR) are associated with different survivals. We evaluated the prognostic influence on event-free survival (EFS) and overall survival (OS) of these responses pre- and post-transplantation in newly diagnosed patients with MM. We analyzed 632 patients from the prospective Grupo Español de Mieloma 2000 protocol who were uniformly treated with vincristine, carmustine, cyclophosphamide, melphalan, and predisone/vincristine, carmustine, adryamcine, and dexamethasone induction followed by high-dose therapy and autologous stem-cell transplantation. Post-transplantation response markedly influenced outcomes. Patients achieving CR had significantly longer EFS (median, 61 v 40 months; P < 10(-5)) and OS (medians not reached; P = .01) versus patients achieving nCR, who likewise had somewhat better outcomes compared with patients achieving PR (median EFS, 34 months, P = .07 v nCR; median OS, 61 months, P = .04). EFS and OS and influence of response were similar among older (age 65 to 70 years) and younger (age < 65 years) patients. Similar findings were observed with pretransplantation response, with trends toward EFS (P = .1; P = .05) and OS (P = .1; P = .07) benefit in patients achieving CR versus nCR and PR, respectively. Post-transplantation response was markedly influenced by pretransplantation response; improvements in response were associated with prolonged survival. Quality of response post-transplantation, notably CR, is significantly associated with EFS and OS prolongation in newly diagnosed patients with MM. There were trends toward similar associations with pretransplantation response status. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1527-7755 |
| العلاقة: | https://doi.org/10.1200/JCO.2008.17.9721Test; Lahuerta, J. J., Mateos, M. V., Martínez-López, J., Rosinol, L., Sureda, A., de la Rubia, J., . & San Miguel, J. F. (2008). Influence of pre-and post-transplantation responses on outcome of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survival. Journal of Clinical Oncology, 26(35), 5775-5782. doi:10.1200/JCO.2008.17.9721. Epub 2008 Nov 10. PMID: 19001321.; http://hdl.handle.net/10366/154330Test |
| DOI: | 10.1200/JCO.2008.17.9721 |
| الإتاحة: | https://doi.org/10.1200/JCO.2008.17.9721Test http://hdl.handle.net/10366/154330Test |
| حقوق: | info:eu-repo/semantics/embargoedAccess |
| رقم الانضمام: | edsbas.2CCA1A4E |
| قاعدة البيانات: | BASE |
| تدمد: | 15277755 |
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| DOI: | 10.1200/JCO.2008.17.9721 |