يعرض 1 - 10 نتائج من 38 نتيجة بحث عن '"(1"', وقت الاستعلام: 1.02s تنقيح النتائج
  1. 1
    Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator

    المؤلفون: Xiaomin Wang, Richard Hargreaves, Julie V. Selkirk, Sekhar Surapaneni, Jennifer Brooks, Yingzhuo Grace Yan, Peijin Zhang, Deepak Dalvie, Gondi Kumar, Maria Palmisano, Jonathan Q. Tran, Usha Yerramilli, April Bai

    المصدر: Drug Metabolism and Disposition. 49:405-419

    مصطلحات موضوعية: Adult, Male, Sphingosine 1 Phosphate Receptor Modulators, Metabolite, Administration, Oral, Pharmaceutical Science, Aldehyde dehydrogenase, CHO Cells, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, 0302 clinical medicine, Cricetinae, Animals, Humans, Sphingosine-1-Phosphate Receptors, Active metabolite, ADME, Alcohol dehydrogenase, Pharmacology, Oxadiazoles, biology, Cytochrome P450, Primary metabolite, Metabolism, Middle Aged, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Indans, biology.protein

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9062b8ce5aa2ba048a27c73bf81ad566Test
    https://doi.org/10.1124/dmd.120.000220Test


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  2. 2
    Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

    المؤلفون: T. Thanga Mariappan, Petia Shipkova, Joseph L. Cantone, Prabhakar Rajanna, Hong Shen, Jinping Gan, W. Griffith Humphreys, Shashyendra Singh Gautam, Dieter M. Drexler, Yueping Zhang, Vinay K. Holenarsipur, Punit Marathe

    المصدر: Journal of Pharmacology and Experimental Therapeutics. 368:136-145

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Pyridoxic Acid, Adolescent, Organic anion transporter 1, Endogeny, Organic Anion Transporters, Sodium-Independent, Pharmacology, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Organic Anion Transport Protein 1, 0302 clinical medicine, Healthy volunteers, Humans, Medicine, Cross-Over Studies, biology, business.industry, Homovanillic acid, Reproducibility of Results, Furosemide, Middle Aged, Crossover study, Healthy Volunteers, Probenecid, 030104 developmental biology, chemistry, biology.protein, Molecular Medicine, business, Biomarkers, 030217 neurology & neurosurgery, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90699d7ec3940e0a5942d9f499048583Test
    https://doi.org/10.1124/jpet.118.252643Test


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  3. 3
    GDC-0810 Pharmacokinetics and Transporter-Mediated Drug Interaction Evaluation with an Endogenous Biomarker in the First-in-Human, Dose Escalation Study

    المؤلفون: Buyun Chen, Roland Morley, Kenta Yoshida, Kit Wun Kathy Cheung, Lichuan Liu, Iris T Chan, Sravanthi Cheeti, Srikumar Sahasranaman

    المصدر: Drug Metabolism and Disposition. 47:966-973

    مصطلحات موضوعية: Adult, Coproporphyrins, Indazoles, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Breast Neoplasms, Pharmacology, 030226 pharmacology & pharmacy, Solute Carrier Organic Anion Transporter Family Member 1B3, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, Humans, Drug Interactions, Receptor, Aged, Dose-Response Relationship, Drug, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Transporter, Middle Aged, Drug interaction, Bioavailability, Organic anion-transporting polypeptide, Receptors, Estrogen, Cinnamates, 030220 oncology & carcinogenesis, biology.protein, Feasibility Studies, Biomarker (medicine), Female, Biomarkers, Half-Life

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402261aa975f59481f6e620526e8cc35Test
    https://doi.org/10.1124/dmd.119.087924Test


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  4. 4
    Translation of In Vitro Transport Inhibition Studies to Clinical Drug-Drug Interactions for Glecaprevir and Pibrentasvir

    المؤلفون: Matthew P. Kosloski, Jens Kort, Ryota Kikuchi, Haoyu Wang, Wei Liu, Elaine J. Kim, Federico J. Mensa, Kennan C. Marsh, Daniel A.J. Bow

    المصدر: Journal of Pharmacology and Experimental Therapeutics. 370:278-287

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Pyrrolidines, Organic anion transporter 1, Sofosbuvir, Cmax, Pharmacology, Translational Research, Biomedical, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Quinoxalines, medicine, Humans, Drug Interactions, Tissue Distribution, Rosuvastatin, Aged, Sulfonamides, biology, Chemistry, Membrane Transport Proteins, Biological Transport, Glecaprevir, Middle Aged, Healthy Volunteers, Pibrentasvir, Organic anion-transporting polypeptide, Drug Combinations, 030104 developmental biology, biology.protein, Molecular Medicine, Benzimidazoles, Female, 030217 neurology & neurosurgery, Pravastatin, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2e3d9295942f5bd2fcf1be70ed3514Test
    https://doi.org/10.1124/jpet.119.256966Test


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  5. 5
    Facilitation of Chemotaxis Activity of Mesenchymal Stem Cells via Stromal Cell–Derived Factor-1 and Its Receptor May Promote Ectopic Ossification of Human Spinal Ligaments

    المؤلفون: Shigeru Motomura, Yasuyuki Ishibashi, Keigo Kurotaki, Shunpei Nagasaki, Ken-Ichi Furukawa, Gentaro Kumagai, Kanichiro Wada, Shunfu Chin

    المصدر: Journal of Pharmacology and Experimental Therapeutics. 369:1-8

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Receptors, CXCR4, Pathology, medicine.medical_specialty, Stromal cell, Matrix (biology), CXCR4, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Stromal cell-derived factor 1, CXC chemokine receptors, Aged, Aged, 80 and over, Pharmacology, Ligaments, biology, Ossification, Chemotaxis, Ossification, Heterotopic, Mesenchymal stem cell, Mesenchymal Stem Cells, Middle Aged, Chemokine CXCL12, Spine, Protein Transport, 030104 developmental biology, biology.protein, Molecular Medicine, Immunohistochemistry, Female, medicine.symptom, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc2c95b33f42e7e27ff54c481ba782cTest
    https://doi.org/10.1124/jpet.118.254367Test


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  6. 6
    Investigation of Endogenous Compounds Applicable to Drug–Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans

    المؤلفون: Kazuya Maeda, Yuri Tsuruya, Koji Kato, Yuji Kumagai, Hiroyuki Kusuhara, Yuichi Sugiyama, Yuichiro Imamura, Yamato Sano

    المصدر: Drug Metabolism and Disposition. 44:1925-1933

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Taurine, Hydrocortisone, Organic anion transporter 1, Pharmaceutical Science, Endogeny, Urine, Organic Anion Transporters, Sodium-Independent, Pharmacology, Kidney, 030226 pharmacology & pharmacy, Benzylpenicillin, Cell Line, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Organic Anion Transport Protein 1, 0302 clinical medicine, Pharmacokinetics, medicine, Animals, Humans, Drug Interactions, biology, Probenecid, Kidney metabolism, Penicillin G, HEK293 Cells, 030104 developmental biology, chemistry, biology.protein, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474a3a2f05906c65dd43c76e44c28cecTest
    https://doi.org/10.1124/dmd.116.071472Test


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  7. 7
    Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor

    المؤلفون: Patrick Maurel, Fridolin Treindl, Jean-Michel Fabre, Jeanne Ramos, Hugues de Boussac, Astrid Herrero, Sabine Gerbal-Chaloin, Claire Gondeau, Cédric Duret, Philippe Briolotti, Martine Daujat-Chavanieu, Markus F. Templin, Michael Römer

    المساهمون: Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), University of Tübingen, Center for Bioinformatics (ZBIT), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

    المصدر: Drug Metabolism and Disposition
    Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2018, 46 (3), pp.223-236. ⟨10.1124/dmd.117.078683⟩

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Peroxisome-Targeting Signal 1 Receptor, Transcription, Genetic, Pharmaceutical Science, 03 medical and health sciences, 0302 clinical medicine, Epidermal growth factor, Oximes, Gene expression, Constitutive androstane receptor, Recoverin, Transcriptional regulation, Humans, Gene silencing, Epidermal growth factor receptor, Cells, Cultured, Aged, Pharmacology, Pregnane X receptor, Epidermal Growth Factor, biology, Chemistry, Activator (genetics), [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Middle Aged, Cell biology, ErbB Receptors, Thiazoles, 030104 developmental biology, Gene Expression Regulation, Phenobarbital, 030220 oncology & carcinogenesis, Hepatocytes, biology.protein, Female, human activities, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695057a501f11d298f7dca7935dbf49bTest
    https://doi.org/10.1124/dmd.117.078683Test


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  8. 8
    Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes

    المؤلفون: Gaku Morinaga, Michelle Schaefer, Akiko Matsui, Roderich D. Süssmuth, Gerhard Schänzle, Daniel Bischoff

    المصدر: Drug Metabolism and Disposition. 46:166-177

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, SLC47A1, Organic anion transporter 1, Cell Culture Techniques, Organic Anion Transporters, Pharmaceutical Science, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Humans, Drug Interactions, RNA, Messenger, Pharmacology, SLC10A1, biology, Chemistry, Multidrug resistance-associated protein 2, Biological Transport, Middle Aged, Molecular biology, Multidrug Resistance-Associated Protein 2, Solute carrier family, 030104 developmental biology, Liver, Cell culture, Hepatocytes, Hepatic stellate cell, biology.protein, Female, Efflux

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0e58b462b50992f1ecd95ca4fb06c6Test
    https://doi.org/10.1124/dmd.117.078238Test


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  9. 9
    Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

    المؤلفون: Punit Marathe, Dieter M. Drexler, Robert Langish, Sandhya Mandlekar, Weiqi Chen, Hong Shen, Yurong Lai, W. Griffith Humphreys, Kurex Sidik, Vinay K. Holenarsipur, Jinping Gan, Eric Shields

    المصدر: Drug Metabolism and Disposition. 45:908-919

    مصطلحات موضوعية: Adult, Male, Coproporphyrins, medicine.medical_specialty, Adolescent, Organic anion transporter 1, Cmax, Organic Anion Transporters, Pharmaceutical Science, Endogeny, Palmitic Acids, 030226 pharmacology & pharmacy, Cell Line, Bile Acids and Salts, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dehydroepiandrosterone sulfate, Pharmacokinetics, Internal medicine, medicine, Humans, Drug Interactions, Rosuvastatin Calcium, Pharmacology, chemistry.chemical_classification, biology, Dehydroepiandrosterone Sulfate, Fatty acid, Biological Transport, Middle Aged, Healthy Volunteers, Organic anion-transporting polypeptide, HEK293 Cells, Endocrinology, chemistry, Area Under Curve, 030220 oncology & carcinogenesis, biology.protein, Rifampin, Biomarkers

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b372f3917f3dcf2f1541b24caa44b4c7Test
    https://doi.org/10.1124/dmd.117.075531Test


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  10. 10
    Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin

    المؤلفون: Harma Ellens, Liangfu Chen, May Y K Ho, Marta Johnson, Christopher J Matheny, Dipal Patel

    المصدر: Drug Metabolism and Disposition. 45:27-34

    مصطلحات موضوعية: Adult, Organic anion transporter 1, Organic Anion Transporters, Pharmaceutical Science, CHO Cells, Pharmacology, 030226 pharmacology & pharmacy, Intestinal absorption, Substrate Specificity, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, In vivo, medicine, Animals, Humans, Drug Interactions, Rosuvastatin, Intestinal Mucosa, Rosuvastatin Calcium, IC50, Aged, Cross-Over Studies, Dose-Response Relationship, Drug, Phenylpropionates, biology, Chemistry, Anticholesteremic Agents, Multidrug resistance-associated protein 2, nutritional and metabolic diseases, Transporter, Middle Aged, Healthy Volunteers, Organic anion-transporting polypeptide, HEK293 Cells, Intestinal Absorption, 030220 oncology & carcinogenesis, Indans, biology.protein, Female, Receptors, Calcium-Sensing, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d71167e70cb2e1ab5b90ebdc2df707eTest
    https://doi.org/10.1124/dmd.116.072397Test


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