التفاصيل البيبلوغرافية
| العنوان: |
Comparative efficacy and safety of 3-day azithromycin and 10-day penicillin V treatment of group A beta-hemolytic streptococcal pharyngitis in children |
| المؤلفون: |
Pacifico, L, Scopetti, F, Ranucci, A, Pataracchia, M, Savignoni, F, Chiesa, C |
| المصدر: |
Antimicrobial Agents and Chemotherapy ; volume 40, issue 4, page 1005-1008 ; ISSN 0066-4804 1098-6596 |
| بيانات النشر: |
American Society for Microbiology |
| سنة النشر: |
1996 |
| الوصف: |
The efficacy and safety of a 3-day course of azithromycin oral suspension (10 mg/kg of body weight once daily) were compared with those of penicillin V (50,000 U/kg/day in two divided doses) in children aged 3 to 12 years for the treatment of symptomatic pharyngitis caused by the group A beta-hemolytic streptococcus (GABHS). For the 154 evaluable patients, the original infecting strain of GABHS was eliminated at the end of follow-up (34 to 36 days after treatment started) from 67 (85.8%) of 78 penicillin-treated patients and 41 (53.9%) of 76 azithromycin-treated patients (P < 0.0001). Overall clinical success was achieved in 71 (91.0%) of 78 penicillin V-treated patients and 57 (75.0%) of 76 azithromycin-treated patients (P < 0.05). Potential drug-related adverse events were reported for 5.5 and 8.6% of the penicillin V- and azithromycin-treated patients, respectively (P = 0.6). In the present study, a once-daily (10 mg/kg), 3-day oral regimen of azithromycin was as safe as a 10-day course of penicillin but did not represent an effective alternative to penicillin for the treatment of GABHS pharyngitis, even for those children with azithromycin-susceptible strains. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1128/aac.40.4.1005 |
| DOI: |
10.1128/AAC.40.4.1005 |
| الإتاحة: |
https://doi.org/10.1128/aac.40.4.1005Test |
| حقوق: |
https://journals.asm.org/non-commercial-tdm-licenseTest |
| رقم الانضمام: |
edsbas.FD49C69C |
| قاعدة البيانات: |
BASE |
