Transitions in Oral and Intestinal Microflora Composition and Innate Immune Receptor-Dependent Stimulation during Mouse Development
| العنوان: | Transitions in Oral and Intestinal Microflora Composition and Innate Immune Receptor-Dependent Stimulation during Mouse Development |
|---|---|
| المؤلفون: | Toshifumi Osaka, Mizuho Hasegawa, Kazuki Tawaratsumida, Grace Y. Chen, Hiroyuki Tada, Naohiro Inohara, Takashi Yamazaki, Gabriel Núñez, Satoshi Tsuneda |
| المصدر: | Infection and Immunity. 78:639-650 |
| بيانات النشر: | American Society for Microbiology, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Immunology, Bone Marrow Cells, Biology, Microbiology, Mice, Immune system, NOD2, NOD1, Animals, Intestinal Mucosa, Receptor, Mice, Knockout, Host Response and Inflammation, Innate immune system, Macrophages, Mouth Mucosa, Pattern recognition receptor, Immunity, Innate, TLR2, Infectious Diseases, Immune System, Receptors, Pattern Recognition, TLR4, Parasitology |
| الوصف: | Commensal bacteria possess immunostimulatory activities that can modulate host responses to affect development and homeostasis in the intestine. However, how different populations of resident bacteria stimulate the immune system remains largely unknown. We characterized here the ability of intestinal and oral microflora to stimulate individual pattern recognition receptors (PRRs) in bone marrow-derived macrophages and mesothelial cells. The intestinal but not oral microflora elicited age- and cell type-specific immunostimulation. The immunostimulatory activity of the intestinal microflora varied among individual mice but was largely mediated via Toll-like receptor 4 (TLR4) during breast-feeding, whereas it became TLR4 independent after weaning. This transition was associated with a change from a microflora rich in TLR4-stimulatory proteobacteria to one dominated by Bacteroidales and/or Clostridiales that poorly stimulate TLR4. The major stimulatory activity of the intestinal microflora was still intact in NOD1-, NOD2-, TLR2-, TLR4-, TLR5-, TLR9-, TLR11-, ASC-, or RICK-deficient cells but still relied on the adaptor MyD88. These studies demonstrate a transition in the intestinal microflora accompanied by a dynamic change of its ability to stimulate different PRRs which control intestinal homeostasis. |
| تدمد: | 1098-5522 0019-9567 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143126e72cf7e818be336c3d1841eecdTest https://doi.org/10.1128/iai.01043-09Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....143126e72cf7e818be336c3d1841eecd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985522 00199567 |
|---|