Aspergillus tanneri sp. nov., a New Pathogen That Causes Invasive Disease Refractory to Antifungal Therapy
| العنوان: | Aspergillus tanneri sp. nov., a New Pathogen That Causes Invasive Disease Refractory to Antifungal Therapy |
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| المؤلفون: | Steven M. Holland, Les R. Folio, Christina M. Henderson, Lily P. Clark, Kyung J. Kwon-Chung, Adrian M. Zelazny, Yvonne R. Shea, Gregory Riedlinger, Janyce A. Sugui, Stephen W. Peterson, Christa S. Zerbe, Glenn Nardone |
| المصدر: | Journal of Clinical Microbiology. 50:3309-3317 |
| بيانات النشر: | American Society for Microbiology, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Microbiology (medical), Antifungal Agents, Adolescent, Itraconazole, Molecular Sequence Data, Microbial Sensitivity Tests, Mycology, Granulomatous Disease, Chronic, Aspergillosis, Aspergillus fumigatus, Microbiology, Fungal Proteins, Mice, Young Adult, Chronic granulomatous disease, Drug Resistance, Fungal, Amphotericin B, medicine, Animals, Cluster Analysis, Humans, Treatment Failure, DNA, Fungal, Lung, Phylogeny, Voriconazole, Microscopy, Aspergillus, Fungal protein, biology, Sequence Analysis, DNA, Triazoles, medicine.disease, biology.organism_classification, Pyrimidines, Tomography, X-Ray Computed, medicine.drug |
| الوصف: | The most common cause of invasive aspergillosis (IA) in patients with chronic granulomatous disease (CGD) is Aspergillus fumigatus followed by A. nidulans ; other aspergilli rarely cause the disease. Here we review two clinical cases of fatal IA in CGD patients and describe a new etiologic agent of IA refractory to antifungal therapy. Unlike typical IA caused by A. fumigatus , the disease caused by the new species was chronic and spread from the lung to multiple adjacent organs. Mycological characteristics and the phylogenetic relationship with other aspergilli based on the sequence analysis of Mcm7 , RPB2 , and Tsr1 indicated that the new species, which we named as A. tanneri , belongs to Aspergillus section Circumdati . The species has a higher amphotericin B, voriconazole, and itraconazole MIC and causes more chronic infection in CGD mice than A. fumigatus . This is the first report documenting IA in CGD patients caused by a species belonging to the Aspergillus section Circumdati that is inherently resistant to azoles and amphotericin B. Unlike the results seen with many members of Aspergillus section Circumdati , ochratoxin was not detected in filtrates of cultures grown in various media. Our phenotypic and genetic characterization of the new species and the case reports will assist future diagnosis of infection caused by A. tanneri and lead to more appropriate patient management. |
| تدمد: | 1098-660X 0095-1137 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f669aadb5fd709c9ca75f707c75fe7Test https://doi.org/10.1128/jcm.01509-12Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f7f669aadb5fd709c9ca75f707c75fe7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1098660X 00951137 |
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