Candida glabrata : Review of Epidemiology, Pathogenesis, and Clinical Disease with Comparison to C. albicans
| العنوان: | Candida glabrata : Review of Epidemiology, Pathogenesis, and Clinical Disease with Comparison to C. albicans |
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| المؤلفون: | Jose A. Vazquez, Jack D. Sobel, Paul L. Fidel |
| المصدر: | Clinical Microbiology Reviews. 12:80-96 |
| بيانات النشر: | American Society for Microbiology, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Microbiology (medical), Epidemiology, Population, Biology, Article, Microbiology, Flucytosine, Immunity, Amphotericin B, Candida albicans, medicine, Animals, Humans, education, Mycosis, Candida, education.field_of_study, General Immunology and Microbiology, Candida glabrata, Candidiasis, Public Health, Environmental and Occupational Health, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Corpus albicans, stomatognathic diseases, Infectious Diseases, Immunology, Female, medicine.drug |
| الوصف: | SUMMARY Until recently, Candida glabrata was considered a relatively nonpathogenic commensal fungal organism of human mucosal tissues. However, with the increased use of immunosuppressive agents, mucosal and systemic infections caused by C. glabrata have increased significantly, especially in the human immunodeficiency virus-infected population. A major obstacle in C. glabrata infections is their innate resistance to azole antimycotic therapy, which is very effective in treating infections caused by other Candida species. Candida glabrata, formerly known as Torulopsis glabrata, contrasts with other Candida species in its nondimorphic blastoconidial morphology and haploid genome. C. glabrata currently ranks second or third as the causative agent of superficial (oral, esophageal, vaginal, or urinary) or systemic candidal infections, which are often nosocomial. Currently, however, there are few recognized virulence factors of C. glabrata and little is known about the host defense mechanisms that protect against infection. Two established animal models (systemic and vaginal) have been established to study treatment, pathogenesis, and immunity. Treatment of C. glabrata infections can include azoles but often requires amphotericin B or flucytosine. This review summarizes all known clinical and experimental information about C. glabrata infections with comparisons to C. albicans as a means of contrasting the two species commonly observed and emphasizing the many recognized differences. |
| تدمد: | 1098-6618 0893-8512 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28aeed5c6b387f2c5430a9782ac7072Test https://doi.org/10.1128/cmr.12.1.80Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d28aeed5c6b387f2c5430a9782ac7072 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986618 08938512 |
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