Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study
| العنوان: | Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study |
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| المؤلفون: | Goran Stevanovic, Tania Martin-Peñaranda, Virginia Pomar, Cristian Tebé, Esther Moga, Mercedes García-Gasalla, Adrián Sánchez-Montalvá, Thomas B. Schön, Ivana Mareković, María Elvira Balcells, Ramón Rabuñal-Rey, Diego Vicente, Verónica Rubio, Deniz Gazel, María Teresa Tórtola, Tekin Karsligil, S. Perez-Recio, Ivana Goić-Barišić, Silvia Campos-Gutiérrez, Nazan Bayram, Rodrigo Naves, Ilkay Karaoglan, Laura Barcia, Miguel Santin, Delia Goletti, Natalia Pallares, Natalia Montiel, Luis Anibarro, Jakob Paues, Matilde Trigo, Isabel Suárez-Toste, Aleksandra Barac, Maria D Grijota-Camino, Fernando Alcaide, José María Barcala, María J Gude-Gonzalez, Juana Cacho-Calvo |
| المصدر: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Microbiology Spectrum r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Microbiology Spectrum, Vol 9, Iss 3 (2021) Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | American Society for Microbiology, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, diagnosis, Physiology, latent tuberculosis infection, QuantiFERON-TB gold plus, tuberculosis-specific CD8 T cells, Tuberculosis-specific CD8 T cells, CD8-Positive T-Lymphocytes, Proves funcionals (Medicina), 0302 clinical medicine, Diagnosis, Interferon gamma, 030212 general & internal medicine, Ecology, Function tests (Medicine), Middle Aged, QR1-502, 3. Good health, Dermatology and Venereal Diseases, Antigens, Bacterial / immunology, CD8-Positive T-Lymphocytes / immunology, Infectious Diseases, Cohort, Interferon-gamma / immunology, Female, Research Article, medicine.drug, Adult, Risk, Tuberculosis / diagnosis, Microbiology (medical), medicine.medical_specialty, Latent Tuberculosis / diagnosis, Tuberculosis, Tuberculosi, Microbiology, Sensitivity and Specificity, Mycobacterium tuberculosis / immunology, Interferon-gamma, 03 medical and health sciences, Antigen, Latent Tuberculosis, Internal medicine, Genetics, medicine, Humans, Dermatologi och venereologi, Latent tuberculosis infection, Interferon-gamma Release Tests / methods, Aged, Antigens, Bacterial, General Immunology and Microbiology, business.industry, Environmental Exposure, Mycobacterium tuberculosis, Cell Biology, Odds ratio, TUBERCULOSIS EXPOSURE, medicine.disease, Confidence interval, Contact Tracing / methods, 030228 respiratory system, Multicenter study, Environmental Exposure / analysis, Contact Tracing, business, Interferon-gamma Release Tests |
| الوصف: | We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB2-TB1 value.0.6 IU.ml(-1) was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2>TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB2-TB1 result of >0.6 IU.ml(-1) and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2>TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB2-TB1 difference of.0.6 IU.ml(-1) was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection. IMPORTANCE Contact tuberculosis tracing is essential to identify recently infected people, who therefore merit preventive treatment. However, there are no diagnostic tests that can determine whether the infection is a result of a recent exposure or not. It has been suggested that by using the QuantiFERON-TB gold plus, an interferon gamma (IFN-gamma) release assay, a difference in IFN-gamma production between the two antigen tubes (TB2 minus TB1) of.0.6 IU.ml(-1) could serve as a proxy marker for recent infection. In this large multinational study, infected individuals could not be classified according to the risk of recent exposure based on differences in IFN- g in TB1 and TB2 tubes that were higher than 0.6 IU.ml(-1). QuantiFERON-TB gold plus is not able to distinguish between recent and remotely acquired tuberculosis infection, and it should not be used for that purpose in contact tuberculosis tracing. Funding Agencies|Department of Clinical Sciences of the University of Barcelona |
| وصف الملف: | application/pdf |
| تدمد: | 2165-0497 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc070436e59813b0bb2f6d383e03042Test https://doi.org/10.1128/spectrum.00972-21Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2cc070436e59813b0bb2f6d383e03042 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21650497 |
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