دورية أكاديمية
Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent.
| العنوان: | Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent. |
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| المؤلفون: | Steinig, Eike J, Duchene, Sebastian, Robinson, D Ashley, Monecke, Stefan, Yokoyama, Maho, Laabei, Maisem, Slickers, Peter, Andersson, Patiyan, Williamson, Deborah, Kearns, Angela, Goering, Richard V, Dickson, Elizabeth, Ehricht, Ralf, Ip, Margaret, O'Sullivan, Matthew VN, Coombs, Geoffrey W, Petersen, Andreas, Brennan, Grainne, Shore, Anna C, Coleman, David C, Pantosti, Annalisa, de Lencastre, Herminia, Westh, Henrik, Kobayashi, Nobumichi, Heffernan, Helen, Strommenger, Birgit, Layer, Franziska, Weber, Stefan, Aamot, Hege Vangstein, Skakni, Leila, Peacock, Sharon J, Sarovich, Derek, Harris, Simon, Parkhill, Julian, Massey, Ruth C, Holden, Mathew TG, Bentley, Stephen D, Tong, Steven YC |
| بيانات النشر: | American Society for Microbiology //dx.doi.org/10.1128/mbio.01105-19 mBio |
| سنة النشر: | 2019 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Bengal Bay, CA-MRSA, India, ST772, South Asia, Staphylococcus aureus, WGS, antimicrobial resistance, genomic epidemiology, global transmission, phenotyping, phylodynamics, Anti-Bacterial Agents, Asia, Community-Acquired Infections, Drug Resistance, Multiple, Bacterial, Evolution, Molecular, Genome, Humans, Methicillin-Resistant Staphylococcus aureus, Phylogeny, Staphylococcal Infections |
| الوصف: | The evolution and global transmission of antimicrobial resistance have been well documented for Gram-negative bacteria and health care-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which similar processes occur with Gram-positive bacteria in the community setting is less well understood. In this study, we traced the recent origins and global spread of a multidrug-resistant, community-associated Staphylococcus aureus lineage from the Indian subcontinent, the Bengal Bay clone (ST772). We generated whole-genome sequence data of 340 isolates from 14 countries, including the first isolates from Bangladesh and India, to reconstruct the evolutionary history and genomic epidemiology of the lineage. Our data show that the clone emerged on the Indian subcontinent in the early 1960s and disseminated rapidly in the 1990s. Short-term outbreaks in community and health care settings occurred following intercontinental transmission, typically associated with travel and family contacts on the subcontinent, but ongoing endemic transmission was uncommon. Acquisition of a multidrug resistance integrated plasmid was instrumental in the emergence of a single dominant and globally disseminated clade in the early 1990s. Phenotypic data on biofilm, growth, and toxicity point to antimicrobial resistance as the driving force in the evolution of ST772. The Bengal Bay clone therefore combines the multidrug resistance of traditional health care-associated clones with the epidemiological transmission of community-associated methicillin-resistant S. aureus (MRSA). Our study demonstrates the importance of whole-genome sequencing for tracking the evolution of emerging and resistant pathogens. It provides a critical framework for ongoing surveillance of the clone on the Indian subcontinent and elsewhere.IMPORTANCE The Bengal Bay clone (ST772) is a community-associated and multidrug-resistant Staphylococcus aureus lineage first isolated from Bangladesh and India in 2004. In this ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Electronic; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/300536Test |
| DOI: | 10.17863/CAM.47610 |
| الإتاحة: | https://doi.org/10.17863/CAM.47610Test https://www.repository.cam.ac.uk/handle/1810/300536Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.1FBC8D74 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.47610 |
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