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Association of Major Histocompatibility Complex Class 1 Chain-Related Gene A Dimorphism with Type 1 Diabetes and Latent Autoimmune Diabetes in Adults in the Algerian Population

التفاصيل البيبلوغرافية
العنوان: Association of Major Histocompatibility Complex Class 1 Chain-Related Gene A Dimorphism with Type 1 Diabetes and Latent Autoimmune Diabetes in Adults in the Algerian Population
المؤلفون: Amel Heniche, Aissa Boudiba, Habiba Amroun, S. Mimouni, Thibaud Gervais, Amel Benyahia, Khadidja Belanteur, Malha Azzouz, Rachida Raache, Nabila Attal, Dominique Latinne, M.C. Abbadi
المساهمون: UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de biologie hématologique
المصدر: Clinical and Vaccine Immunology (Print), Vol. 19, no.4, p. 557-561 (2012)
بيانات النشر: American Society for Microbiology, 2012.
سنة النشر: 2012
مصطلحات موضوعية: Microbiology (medical), Adult, Male, Adolescent, Genotype, Clinical Biochemistry, Immunology, Population, Single-nucleotide polymorphism, Biology, Young Adult, Gene Frequency, medicine, Immunology and Allergy, Humans, Allele, education, Allele frequency, Genetic Association Studies, Genetics, education.field_of_study, Type 1 diabetes, Haplotype, Histocompatibility Antigens Class I, Middle Aged, medicine.disease, Genotype frequency, stomatognathic diseases, Diabetes Mellitus, Type 1, Algeria, Clinical Immunology, Female
الوصف: Major histocompatibility complex class I chain-related gene A (MICA-129) dimorphism was investigated in 73 autoimmune diabetes patients (type 1 diabetes and latent autoimmune diabetes in adults) and 75 controls from Algeria. Only MICA-129 Val allele and MICA-129 Val/Val genotype frequencies were higher among patients than in the control group. Statistical analysis of the estimated extended HLA-DR-DQ-MICA haplotypes shown that individual effects of MICA alleles on HLA-DQ2-DR3-MICA-129 Val/Val and HLA-DQ8-DR4-MICA-129 Val/Val haplotypes were significantly higher in patients than in the control groups. These preliminary data might suggest a relevant role of MICA-129 Val/Val single nucleotide polymorphism (weak/weak binders of NKG2D receptor) in the pathogenesis of T1D and LADA.
اللغة: English
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7456557f6debadb71cd9fa25a974f05fTest
https://europepmc.org/articles/PMC3318287Test/
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....7456557f6debadb71cd9fa25a974f05f
قاعدة البيانات: OpenAIRE
الوصف
الوصف غير متاح.