المؤلفون: Yuki, Sasaki, Hideki, Arimochi, Kunihiro, Otsuka, Hiroyuki, Kondo, Shin-Ichi, Tsukumo, Koji, Yasutomo

المصدر: JCI Insight. 7

مصطلحات موضوعية: Chemokine CXCL10, Inflammation, Mice, Proteasome Endopeptidase Complex, Receptors, CXCR3, Lipodystrophy, Mutation, Animals, General Medicine, Proteasome Inhibitors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94708e8990231a2dd27bc48555234f92Test
https://doi.org/10.1172/jci.insight.152681Test

المؤلفون: Dan Li, Sagar Lonial, Lina Song, Sumin Kang, Kelly R. Magliocca, Anna Umano, Zhuo Georgia Chen, Dong M. Shin, Jaemoo Chun, Austin C. Boese, Jie Li, Nabil F. Saba, JiHoon Kang, Taofeek K. Owonikoko, Chaoyun Pan, Lingtao Jin, Yunhan Jiang

المصدر: Journal of Clinical Investigation. 129:4110-4123

مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Mice, Nude, Protein Serine-Threonine Kinases, Hsp90 inhibitor, Mice, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Cell Line, Tumor, Heat shock protein, medicine, Animals, Humans, HSP90 Heat-Shock Proteins, Cisplatin, Binding Sites, biology, Protein Stability, Kinase, Chemistry, Lestaurtinib, Ubiquitination, General Medicine, Xenograft Model Antitumor Assays, Ubiquitin ligase, HEK293 Cells, 030104 developmental biology, Amino Acid Substitution, A549 Cells, Drug Resistance, Neoplasm, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer cell, Mutagenesis, Site-Directed, biology.protein, Cancer research, Female, Microtubule-Associated Proteins, Research Article, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8121302ec1fbe0d148347555a76a2171Test
https://doi.org/10.1172/jci125963Test

المؤلفون: Joseph Y. Cheung, Arthur M. Feldman, Jonathan A. Kirk

المصدر: J Clin Invest

مصطلحات موضوعية: Cardiomyopathy, Dilated, Proteasome Endopeptidase Complex, Heart disease, Heart Diseases, Review, Biology, BAG3, Sarcomere, Models, Biological, Heat shock protein, Neoplasms, medicine, Autophagy, Humans, Molecular Targeted Therapy, Receptor, Adaptor Proteins, Signal Transducing, Cancer, General Medicine, Genetic Therapy, medicine.disease, Cell biology, Pancreatic Neoplasms, Cancer cell, Mutation, Apoptosis Regulatory Proteins, Carcinoma, Pancreatic Ductal, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1389eced07f11f538cb1f0801c8307f9Test
https://europepmc.org/articles/PMC8363278Test/

المؤلفون: J. Fah Sathirapongsasuti, Chang Hyeok An, Irfan Rahman, Hilaire C. Lam, Suzanne M. Cloonan, Jonathan Franks, Caroline A. Owen, Abhiram R. Bhashyam, Yohannes Tesfaigzi, Kathleen J. Haley, Hongwei Yao, Jeffery A. Haspel, George R. Washko, Hong Pyo Kim, Anju Singh, Stefan W. Ryter, Augustine M.K. Choi, Bin Shan, Edwin K. Silverman, Shyam Biswal, Morgan Cervo, Kenji Mizumura, Ashfaq Mahmood, Anna L. Chung, John Quackenbush

المصدر: J Clin Invest
2013, ' Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction ', Journal of Clinical Investigation, vol. 123, no. 12, pp. 5212-30 . https://doi.org/10.1172/JCI69636Test

مصطلحات موضوعية: Male, Histone Deacetylase 6, Selective autophagy, Mice, Pulmonary Disease, Chronic Obstructive, Cytosol, Sirtuin 1, Clinical investigation, Medicine, Cells, Cultured, Mice, Knockout, COPD, biology, Cilium, General Medicine, BECN1, Tobacco Products, respiratory system, Phenylbutyrates, Cell biology, Trachea, Phenotype, Beclin-1, Female, Corrigendum, Microtubule-Associated Proteins, Research Article, Proteasome Endopeptidase Complex, Mucociliary clearance, NF-E2-Related Factor 2, Phenylbutyrate, Histone Deacetylases, Autophagy, Animals, Humans, Cilia, business.industry, Ubiquitination, Epithelial Cells, HDAC6, medicine.disease, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, Mucus, Proteostasis, Cancer research, biology.protein, Microscopy, Electron, Scanning, Tobacco Smoke Pollution, business, Apoptosis Regulatory Proteins, Protein Processing, Post-Translational

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd1465f3d2bb98b58eaef74b3ffc5b9Test
https://europepmc.org/articles/PMC7598037Test/

المؤلفون: James D. Londino, John Evankovich, Michael J. Jurczak, Iulia Popescu, Michael M. Myerburg, Travis Lear, Karina C. Lockwood, Yingze Zhang, Yuan Liu, Yao Tong, Bryan J. McVerry, Yanwen Chen, John F. McDyer, Bill B. Chen

مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Interleukin-3 Receptor alpha Subunit, Inflammation, Lung injury, Proinflammatory cytokine, 03 medical and health sciences, Mice, 0302 clinical medicine, Ubiquitin, medicine, Animals, Humans, Innate immune system, biology, Chemistry, Ubiquitination, Membrane Proteins, General Medicine, medicine.disease, Immunity, Innate, Ubiquitin ligase, Cell biology, 030104 developmental biology, RAW 264.7 Cells, Proteasome, 030220 oncology & carcinogenesis, biology.protein, Interleukin-3, medicine.symptom, Cytokine storm, Research Article, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d559cab938f80bdb452b1e9bb3f735Test
https://europepmc.org/articles/PMC7098800Test/

المؤلفون: Yaqun Teng, Yutong Zhao, Li Lan, Mauricio Rojas, Robert Lafyatis, Starr Welty, Chunbin Zou, Jun-Ho Jang, Aki Hoji, Tomasz W. Kaminski, John Sembrat, Toru Nyunoya, Frank C. Sciurba, Xiuying Li, Prithu Sundd, Rama K. Mallampalli, Divay Chandra, Tiffany A. Coon

المصدر: JCI Insight. 5

مصطلحات موضوعية: Male, 0301 basic medicine, Proteasome Endopeptidase Complex, DNA Repair, DNA repair, DNA damage, Ubiquitin-Protein Ligases, Protein subunit, Apoptosis, Cell Line, Mice, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Smoke, Tobacco, Animals, Humans, Lung, Aged, Emphysema, Mice, Knockout, biology, Chemistry, Tumor Suppressor Proteins, Smoking, TACC2, Epithelial Cells, General Medicine, Middle Aged, respiratory tract diseases, Ubiquitin ligase, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Pulmonary Emphysema, Proteasome, 030220 oncology & carcinogenesis, Mutagenesis, Site-Directed, biology.protein, Female, Carrier Proteins, Transcriptome, Research Article, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0263ec8893d492cebd30d820fa9bf9Test
https://doi.org/10.1172/jci.insight.125895Test

المؤلفون: Liangjun Hu, Douglas P. Millay, Qingnian Goh, Alyssa A. W. Cramer, Roger Cornwall, Sia Nikolaou

المصدر: JCI Insight. 4

مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, medicine.medical_specialty, Contracture, Neuromuscular disease, Muscle Proteins, Protein degradation, Cerebral palsy, Bortezomib, Mice, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Animals, Brachial Plexus, Muscle, Skeletal, Muscle contracture, Mice, Knockout, Denervation, business.industry, Stem Cells, Membrane Proteins, PAX7 Transcription Factor, Neuromuscular Diseases, General Medicine, medicine.disease, Disease Models, Animal, 030104 developmental biology, Endocrinology, Animals, Newborn, 030220 oncology & carcinogenesis, Proteasome inhibitor, medicine.symptom, Transcriptome, business, Research Article, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8160648091a50da8007b9f79b5c1739Test
https://doi.org/10.1172/jci.insight.128454Test

المؤلفون: Yogesh Jethava, Guido Tricot, Hua Bai, Mu Hao, Xin Zhan, Lugui Qiu, Ivana Frech, Zhimin Gu, Hasem Habelhah, Fenghuang Zhan, Reinaldo Franqui-Machin

المصدر: Journal of Clinical Investigation. 128:2877-2893

مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Drug resistance, Models, Biological, Bortezomib, Ubiquitin-Specific Peptidase 7, Mice, 03 medical and health sciences, Mice, Inbred NOD, Cell Line, Tumor, medicine, Animals, Humans, NIMA-Related Kinases, Heparanase, Protein kinase B, Multiple myeloma, Cell Proliferation, Glucuronidase, Protein Stability, Kinase, Chemistry, NF-kappa B, Ubiquitination, General Medicine, Prognosis, NFKB1, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Drug Resistance, Neoplasm, Gene Knockdown Techniques, Cancer research, Signal transduction, Multiple Myeloma, Proteasome Inhibitors, Protein Binding, Signal Transduction, Research Article, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe93185b742c7d61a51902f07a852f8Test
https://doi.org/10.1172/jci98765Test

المؤلفون: Lefebvre, Bruno, Benomar, Yacir, Guédin, Aurore, Langlois, Audrey, Hennuyer, Nathalie, Dumont, Julie, Bouchaert, Emmanuel, Dacquet, Catherine, Pénicaud, Luc, Casteilla, Louis, Pattou, Francois, Ktorza, Alain, Staels, Bart, Lefebvre, Philippe

المساهمون: Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Division of Meabolic Diseases, Institut de Recherches Servier, Métabolisme Plasticité et Mitochondrie lié à l'ex IFR 31 (LMPM), IFR 31 Louis Bugnard (IFR 31), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Thérapie cellulaire du diabète, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Division of Metabolic Diseases

المصدر: ISSN: 0021-9738 ; Journal of Clinical Investigation ; https://inserm.hal.science/inserm-00472906Test ; Journal of Clinical Investigation, 2010, 120 (5), pp.1454-68. ⟨10.1172/JCI38606⟩.

مصطلحات موضوعية: MESH: 3T3-L1 Cells, MESH: Adipose Tissue, MESH: PPAR gamma, MESH: Proteasome Endopeptidase Complex, MESH: Retinoid X Receptor alpha, MESH: Thiazolidinediones, MESH: Transcription, Genetic, MESH: Ubiquitin Thiolesterase, MESH: Animals, MESH: Gene Expression Regulation, MESH: Humans, MESH: Insulin Resistance, MESH: Male, MESH: Mice, Obese, MESH: Obesity, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/20364085; inserm-00472906; https://inserm.hal.science/inserm-00472906Test; https://inserm.hal.science/inserm-00472906/documentTest; https://inserm.hal.science/inserm-00472906/file/Lefebvre_et_al_JCI.pdfTest; PUBMED: 20364085

الإتاحة: https://doi.org/10.1172/JCI38606Test
https://inserm.hal.science/inserm-00472906Test
https://inserm.hal.science/inserm-00472906/documentTest
https://inserm.hal.science/inserm-00472906/file/Lefebvre_et_al_JCI.pdfTest

المؤلفون: Kristina I. Rother, Wanxia L. Tsai, Qing Zhou, Elaine F. Remmers, Rhina D. Castillo, Yan Huang, Anja Brehm, Raphaela Goldbach-Mansky, Franziska Sotzny, Yin Liu, Robert Wesley, Bernadette Marrero, Peter W. Hildebrand, Helen J. Lachmann, Deborah L. Stone, André Mégarbané, Ebun Omoyinmi, Adriana Almeida de Jesus, Massimo Gadina, Paul A. Brogan, Antonio Torrelo, Adam L Reinhardt, Angel Vera Casano, Dawn Chapelle, G Montealegre, Phil McCoy, Jae Jin Chae, Lela Kardava, Martin Pelletier, Susan Moir, Suvimol Hill, Elke Krüger, Diane E. Brown, Ling Gao, Abraham Zlotogorski, Angelique Biancotto, Jilian Brady, Hanna Kim, Ivona Aksentijevich, Afzal Sheikh, Daniel L. Kastner, Chyi-Chia Richard Lee, Yongqing Chen

المساهمون: [Brehm,A, Sotzny,F, Krüger,E] Charité-Universitätsmedizin Berlin, Institute of Biochemistry, Berlin, Germany. [Liu,Y, Sheikh,A, Marrero,B, Montealegre,G, Almeida de Jesus,A, Kim,H, Chapelle,D, Huang,Y, Chen,Y, Goldbach-Mansky,R] Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, Maryland, USA. [Sheikh,A, Zhou,Q, Remmers,EF, Chae,JJ, Brady,J, Stone,D, Kastner,DL, Aksentijevich,I] Inflammatory Disease Section, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA. [Omoyinmi,E, Brogan,P] University College London Institute of Child Health and Great Ormond Street Hospital, NHS Foundation Trust, London, United Kingdom. [Biancotto,A, McCoy,P] Center of Human Immunology, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA. [Reinhardt,A] Children’s Hospital and Medical Center and University of Nebraska Medical Center, Omaha, Nebraska, USA. [Pelletier,M] Autoimmunity Branch. [Tsai,WL, Gadina,M] Office of Science and Technology, NIAMS. [Kardava,L, Moir,S] Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases. [Hill,S] Clinical Center, NIH, Bethesda, Maryland, USA. [Lachmann,HJ] National Amyloidosis Centre, University College Medical School, London, United Kingdom. [Megarbane,A] Medical Genetics Unit, Saint Joseph University, Beirut, Lebanon. Institut Jerome Lejeune, Paris, France. [Castillo,RD, Brown,D] Children’s Hospital Los Angeles and University of Southern California, Los Angeles, California, USA. [Vera Castillo,A] Hospital Carlos Haya, Malaga, Andalusia, Spain. [Gao,L] College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. [Lee,CR] Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland, USA. [Torrelo,A] Pediatric Dermatology, Hospital Niño Jesús, Madrid, Spain. [Zlotogorski,A] Hadassah-Hebrew University Medical Center, Jerusalem, Israel. [Wesley,R] Reproductive Biology and Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development. [Rother,KR] Section on Pediatric Diabetes and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, Maryland, USA. [Hildebrand,PW] Charité-Universitätsmedizin Berlin, Institute of Medical Physics and Biophysics, Berlin, Germany., This research was supported by the Intramural Research Program of NIAMS at the NIH, by the Berlin Institute of Health, and by the Deutsche Forschungsgemeinschaft (SFB TR 43 to E. Krüger, SFB740 to E. Krüger and P.W. Hildebrand).

المصدر: Journal of Clinical Investigation. 125:4196-4211

مصطلحات موضوعية: Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings], Lipodystrophy, Transcription, Genetic, PSMA3, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Células cultivadas, Subunidades de proteínas, 0302 clinical medicine, Clinical investigation, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Molecular [Medical Subject Headings], Medicine, Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Interferons::Interferon Type I [Medical Subject Headings], Interferón de tipo I, Chaperonas moleculares, Cells, Cultured, Alineación de secuencias, General Medicine, Pedigree, Enfermedades autoinflamatorias hereditarias, Deleción de secuencias, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease::Syndrome [Medical Subject Headings], Interferon Type I, RNA Interference, Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], Erratum, Fenotipo, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Molecular Chaperones [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings], Genotype, Molecular Sequence Data, Síndrome, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Protein Subunits [Medical Subject Headings], 03 medical and health sciences, Mutación de sentido erróneo, Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Hereditary Autoinflammatory Diseases [Medical Subject Headings], Humans, Secuencia de aminoácidos, Amino Acid Sequence, Loss function, Hereditary Autoinflammatory Diseases, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation::Sequence Deletion [Medical Subject Headings], Fibroblasts, Conformación de proteínas, Transcripción genética, Protein Subunits, Regulación de la expresión génica, 030104 developmental biology, Information Science::Information Science::Information Services::Documentation::Molecular Sequence Data [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic::Gene Silencing::RNA Interference [Medical Subject Headings], Proteasome, Complejo de endopeptidasas de los proteasomas, Anatomy::Cells::Cells, Cultured [Medical Subject Headings], Immunology, Mutation, Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Amino Acid Sequence [Medical Subject Headings], Genotipo, Molecular Chaperones, 0301 basic medicine, Models, Molecular, Protein Conformation, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Pedigree [Medical Subject Headings], Modelos moleculares, Chemicals and Drugs::Macromolecular Substances::Multiprotein Complexes::Multienzyme Complexes::Proteasome Endopeptidase Complex [Medical Subject Headings], Missense mutation, Homología de secuencias de aminoácidos, RNA, Small Interfering, Anatomy::Cells::Connective Tissue Cells::Fibroblasts::Myofibroblasts [Medical Subject Headings], Sequence Deletion, Genetics, Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Small Untranslated::RNA, Small Interfering [Medical Subject Headings], Type I IFN production, Syndrome, Interferencia por ARN, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation::Mutation, Missense [Medical Subject Headings], Phenotype, Research Article, Datos de Secuencia Molecular, Proteasome Endopeptidase Complex, Protein subunit, Mutation, Missense, Biology, Linaje, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription, Genetic [Medical Subject Headings], Mutación, Sequence Homology, Amino Acid, business.industry, PSMB8, Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation::Protein Conformation [Medical Subject Headings], PSMB9, PSMB4, Molecular biology, Fibroblastos, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Alignment [Medical Subject Headings], Gene Expression Regulation, Proteasome assembly, Proteasome maturation protein, business, Sequence Alignment, Phenomena and Processes::Genetic Phenomena::Sequence Homology::Sequence Homology, Amino Acid [Medical Subject Headings], 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84dd172581930722135aed4d91ce961fTest
https://doi.org/10.1172/jci81260Test