التفاصيل البيبلوغرافية
| العنوان: |
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice. |
| المؤلفون: |
Porporato, Paolo E.1, Filigheddu, Nicoletta1, Reano, Simone1, Ferrara, Michele1, Angelino, Elia1, Gnocchi, Viola F.1, Prodam, Flavia2, Ronchi, Giulia3, Fagoonee, Sharmila4, Fornaro, Michele3, Chianale, Federica1, Baldanzi, Gianluca1, Surico, Nicola1, Sinigaglia, Fabiola1, Perroteau, Isabelle5, Smith, Roy G.6, Sun, Yuxiang7, Geuna, Stefano3, Graziani, Andrea1 |
| المصدر: |
Journal of Clinical Investigation. Feb2013, Vol. 123 Issue 2, p611-622. 12p. 1 Chart, 6 Graphs. |
| مصطلحات موضوعية: |
*CACHEXIA, *WASTING syndrome, *GHRELIN, *SKELETAL muscle, *MUSCULAR atrophy, *MULTIPLE sclerosis, *AIDS, *LABORATORY mice |
| مستخلص: |
Cachexia is a wasting syndrome associated with cancer, AIDS, multiple sclerosis, and several other disease states. It is characterized by weight loss, fatigue, loss of appetite, and skeletal muscle atrophy and is associated with poor patient prognosis, making it an important treatment target. Ghrelin is a peptide hormone that stimulates growth hormone (GH) release and positive energy balance through binding to the receptor GHSR-1a. Only acylated ghrelin (AG), but not the unacylated form (UnAG), can bind GHSR-1a; however, UnAG and AG share several GHSR-1a-independent biological activities. Here we investigated whether UnAG and AG could protect against skeletal muscle atrophy in a GHSR-1a-independent manner. We found that both AG and UnAG inhibited dexamethasone-induced skeletal muscle atrophy and atrogene expression through PI3Kß-, mTORC2-, and p38-mediated pathways in myotubes. Upregulation of circulating UnAG in mice impaired skeletal muscle atrophy induced by either fasting or denervation without stimulating muscle hypertrophy and GHSR-1a-mediated activation of the GH/IGF-1 axis. In Ghsr-deficient mice, both AG and UnAG induced phosphorylation of Akt in skeletal muscle and impaired fasting-induced atrophy. These results demonstrate that AG and [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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