المؤلفون: Mehdi Bouhaddou, Rex H. Lee, Hua Li, Neil E. Bhola, Rachel A. O’Keefe, Mohammad Naser, Tian Ran Zhu, Kelechi Nwachuku, Umamaheswar Duvvuri, Adam B. Olshen, Ritu Roy, Aaron Hechmer, Jennifer Bolen, Stephen B. Keysar, Antonio Jimeno, Gordon B. Mills, Scott Vandenberg, Danielle L. Swaney, Daniel E. Johnson, Nevan J. Krogan, Jennifer R. Grandis

المصدر: JCI Insight, Vol 6, Iss 20 (2021)

مصطلحات موضوعية: Therapeutics, Medicine

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2379-3708Test

الوصول الحر: https://doaj.org/article/0965f45254de4190931a8e6473149c38Test

المؤلفون: Lulu Wang, Clemens An, Gordon B. Mills, Xuetong Shen, Yen T. Luu, Wei Zhao, Shumei Song, Lin Yang, Zhenlin Ju, Chen Wang, Wei Zhang, Jianfeng Shen, Timothy A. Yap, Yang Peng, Guang Peng, Jaffer A. Ajani

المصدر: J Clin Invest

مصطلحات موضوعية: 0301 basic medicine, ARID1A, medicine.medical_treatment, Ataxia Telangiectasia Mutated Proteins, Mice, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Cancer immunotherapy, Neoplasms, medicine, Animals, Humans, Innate immune system, biology, Chemistry, Kinase, Membrane Proteins, General Medicine, G2-M DNA damage checkpoint, HCT116 Cells, Nucleotidyltransferases, Immune checkpoint, Neoplasm Proteins, Blockade, DNA-Binding Proteins, Checkpoint Kinase 2, enzymes and coenzymes (carbohydrates), 030104 developmental biology, 030220 oncology & carcinogenesis, Proteolysis, biology.protein, Cancer research, biological phenomena, cell phenomena, and immunity, Signal Transduction, Transcription Factors, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1def25b761f2a0b0c109422b2a11c2Test
https://doi.org/10.1172/jci130445Test

المؤلفون: Xiaoyan Xu, Yiling Lu, Gordon B. Mills, Cristian Rodriguez-Aguayo, Yiu Huen Tsang, Kang Jin Jeong, Kamalika Mojumdar, Zhicheng Zhou, Gabriel Lopez-Berestein, Han Liang, Yumeng Wang, Lingegowda S. Mangala, Anil K. Sood, Shuangxing Yu

المصدر: Journal of Clinical Investigation. 129:5343-5356

مصطلحات موضوعية: 0301 basic medicine, Apoptosis, Biology, Receptors, G-Protein-Coupled, Mice, 03 medical and health sciences, 0302 clinical medicine, Antigens, CD, Cell Line, Tumor, Neoplasms, microRNA, medicine, Animals, Cell Proliferation, Mechanism (biology), Cell growth, Cancer, General Medicine, medicine.disease, In vitro, MicroRNAs, 030104 developmental biology, RNA editing, 030220 oncology & carcinogenesis, Cancer research, Female, RNA Editing, Function (biology), Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7217da87badc6b7a92c28ea1020507Test
https://doi.org/10.1172/jci123396Test

المؤلفون: Shijie Zha, Young Chan Chae, Elaida Dimwamwa, Keith T. Flaherty, Lynn M. Schuchter, Dario C. Altieri, Narayan G. Avadhani, Gao Zhang, Wei Xu, Patricia Brafford, Mengnan Gu, Qin Liu, Batool Shannan, Jephrey Y. Liu, Ashani T. Weeraratna, Manti Guha, Min Xiao, Giorgos C. Karakousis, Satish Srinivasan, Jie Zhang, Devraj Basu, Xiaowei Xu, Dennie T. Frederick, Zhi Wei, Clemens Krepler, Katrin Sproesser, Gordon B. Mills, Tara C. Gangadhar, Harry Choi, Michael A. Davies, Tian Tian, Ravi K. Amaravadi, Abheek Ghosh, Omotayo Ope, Caiyue Xu, Meenhard Herlyn, Yiling Lu, Lawrence Wu, Dongmei Zhang, Weiting Xu, Jennifer A. Wargo, Sergio Randell

المصدر: Journal of Clinical Investigation. 126:1834-1856

مصطلحات موضوعية: Male, 0301 basic medicine, MAPK/ERK pathway, Mitochondrial DNA, Lactams, Macrocyclic, Biology, Mitochondrion, Guanidines, Mitochondrial Dynamics, Article, Hsp90 inhibitor, Mitochondrial Proteins, Mice, 03 medical and health sciences, Animals, Humans, Integrated stress response, HSP90 Heat-Shock Proteins, Extracellular Signal-Regulated MAP Kinases, Melanoma, Protein Kinase Inhibitors, Transcription factor, General Medicine, TFAM, Mitochondria, Neoplasm Proteins, Cell biology, DNA-Binding Proteins, 030104 developmental biology, Mitochondrial biogenesis, Female, Transcription Factors, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74e94cfd6e0f67de1b11babaf588419Test
https://doi.org/10.1172/jci82661Test

المؤلفون: Michelle I. Savage, Jamal Hill, Powel H. Brown, Dekuang Zhao, Gordon B. Mills, Abhijit Mazumdar, Jing Zhao, Yun Zhang, Zachary C. Hartman, Graham M. Poage

المصدر: Journal of Clinical Investigation. 125:2707-2720

مصطلحات موضوعية: CA15-3, Oncology, medicine.medical_specialty, Gene Expression, Mice, Nude, Breast Neoplasms, P70-S6 Kinase 1, Biology, medicine.disease_cause, Mice, Breast cancer, Cell Line, Tumor, Internal medicine, medicine, Animals, Humans, Molecular Targeted Therapy, RNA, Messenger, RNA, Neoplasm, RNA, Small Interfering, PI3K/AKT/mTOR pathway, Cell Proliferation, Ovarian Neoplasms, Cell growth, TOR Serine-Threonine Kinases, Cancer, General Medicine, Genes, p53, medicine.disease, Xenograft Model Antitumor Assays, Pancreatic Neoplasms, Death-Associated Protein Kinases, Receptors, Estrogen, Gene Knockdown Techniques, Mutation, Cancer cell, Cancer research, Female, Tumor Suppressor Protein p53, Carcinogenesis, Signal Transduction, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0b6871d8866fc41f1d31954dbc868fTest
https://doi.org/10.1172/jci70805Test

المؤلفون: Zachary A. Cooper, Keith T. Flaherty, John P. Miller, Genevieve M. Boland, Dennie T. Frederick, Jennifer A. Wargo, Lynda Chin, Sahil Seth, Timothy L. Helms, Gordon B. Mills, Alexei Protopopov, Shan Jiang, Xingzhi Song, Jennifer Kamara, Lawrence N. Kwong, Ahmad T. Akid

المصدر: Journal of Clinical Investigation. 125:1459-1470

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, MAPK/ERK pathway, Transgene, Melanoma, Experimental, Antineoplastic Agents, Biology, medicine.disease_cause, DNA sequencing, Mice, Oximes, medicine, Animals, Humans, Transgenes, Melanoma, Protein Kinase Inhibitors, Genetics, Mutation, Gene Expression Profiling, Imidazoles, PTEN Phosphohydrolase, RNA, General Medicine, medicine.disease, Neoplasm Proteins, 3. Good health, Gene expression profiling, Tamoxifen, Drug Resistance, Neoplasm, Doxycycline, Cancer research, Protein microarray, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535b173e7294e5050d1cdc9b444337ffTest
https://doi.org/10.1172/jci78954Test

المؤلفون: Monica V. Estrada, Monica Rizzo, Mark C. Kelley, Maria G. Kuba, Carlos L. Arteaga, Ingrid A. Mayer, Luis J. Schwarz, Ana M. Gonzalez-Angulo, Monica Red-Brewer, Joan T. Garrett, Gordon B. Mills, Justin M. Balko, Emily M. Fox, Ingrid M. Meszoely, Vandana G. Abramson

المصدر: Journal of Clinical Investigation. 124:5490-5502

مصطلحات موضوعية: medicine.drug_class, Morpholines, Dasatinib, Mutation, Missense, Aminopyridines, Mice, Nude, Estrogen receptor, Breast Neoplasms, Biology, Gene Expression Regulation, Enzymologic, src Homology Domains, Mice, Phosphatidylinositol 3-Kinases, Breast cancer, Estrogen Receptor Modulators, LYN, medicine, Animals, Humans, Src family kinase, Phosphorylation, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Aromatase inhibitor, Fulvestrant, Drug Synergism, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, 3. Good health, Gene Expression Regulation, Neoplastic, Thiazoles, Pyrimidines, src-Family Kinases, Amino Acid Substitution, Receptors, Estrogen, Drug Resistance, Neoplasm, Cancer research, Female, Research Article, medicine.drug, Proto-oncogene tyrosine-protein kinase Src

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cb97cd0d1fe0f153a9a8828eeea9a6Test
https://doi.org/10.1172/jci72573Test

المؤلفون: Gordon B. Mills, Yu Shyr, Bryan T. Hennessy, Carlos L. Arteaga, Emily M. Fox, Catherine F. Higham, Heidi Chen, Ana M. Gonzalez-Angulo, Todd W. Miller, Carlos Garcia-Echeverria

المصدر: Journal of Clinical Investigation. 120:2406-2413

مصطلحات موضوعية: medicine.drug_class, Estrogen receptor, Apoptosis, Breast Neoplasms, Biology, Phosphatidylinositol 3-Kinases, Breast cancer, medicine, Humans, Phosphorylation, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Sirolimus, Estradiol, Kinase, Estrogen Receptor alpha, Cancer, Estrogens, General Medicine, medicine.disease, Hormones, Receptors, Estrogen, Estrogen, Cancer research, Female, Proto-Oncogene Proteins c-akt, Estrogen receptor alpha, Signal Transduction, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509bfe49ecee541ebd3d0b17f5824593Test
https://doi.org/10.1172/jci41680Test

المؤلفون: Jun Sun, Bryan T. Hennessy, Joyce M. Slingerland, Zafar Nawaz, Kathy Chun, Chris Mcmahon, Angel Arnaout, Gordon B. Mills, Arun Seth, Isabel Chu, Sophie Loiseau

المصدر: Journal of Clinical Investigation. 117:2205-2215

مصطلحات موضوعية: Proteasome Endopeptidase Complex, Transcription, Genetic, medicine.drug_class, Proteolysis, Estrogen receptor, Breast Neoplasms, Biology, Enzyme activator, Ubiquitin, Cell Line, Tumor, medicine, Humans, RNA, Messenger, RNA, Neoplasm, RNA, Small Interfering, Protein Kinase Inhibitors, medicine.diagnostic_test, Estrogen Receptor alpha, Estrogens, General Medicine, Prognosis, Neoplasm Proteins, Enzyme Activation, Gene Expression Regulation, Neoplastic, src-Family Kinases, Proteasome, Estrogen, biology.protein, Cancer research, Female, Protein Processing, Post-Translational, Estrogen receptor alpha, Research Article, Proto-oncogene tyrosine-protein kinase Src

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33a5050eaad0d206886a53b066ec43eTest
https://doi.org/10.1172/jci21739Test

المؤلفون: Gordon B. Mills, Jim C. Norman, Yosef Yarden, Igor Jurisica

المصدر: Journal of Clinical Investigation.

مصطلحات موضوعية: Receptor recycling, Breast cancer, medicine, Cancer research, Cancer, General Medicine, GTPase, Rab, Amplicon, Biology, Endocytosis, medicine.disease, Metastasis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d39786ff94605a8827e908017e02c485Test
https://doi.org/10.1172/jci40256Test